BLM (human), recombinant protein

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABS-PP-7652-L.20	20 µg		-	-	Request delivery time estimate		115.00€
ABS-PP-7652-L.100	100 µg		-	-	Request delivery time estimate		205.00€

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Protein function: ATP-dependent DNA helicase that unwinds single- and double- stranded DNA in a... more

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Product information "BLM (human), recombinant protein"

Protein function: ATP-dependent DNA helicase that unwinds single- and double- stranded DNA in a 3'-5' direction (PubMed:9388193, PubMed:24816114, PubMed:25901030). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single- stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (PubMed:20639533, PubMed:24257077, PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks. [The UniProt Consortium]

Keywords:	RecQ-like DNA helicase BLM, Bloom syndrome protein, DNA helicase, RecQ-like type 2, RecQ2, RecQ protein-like 3, Recombinant Human BLM Protein
Supplier:	Absea
Supplier-Nr:	PP-7652-L

Properties

Conjugate:	No
Host:	E.coli
Species reactivity:	human
MW:	45 kD
Format:	Lyophilized

Database Information

KEGG ID :	K10901 \| Matching products
UniProt ID :	P54132 \| Matching products
Gene ID :	GeneID 641 \| Matching products

Handling & Safety

Storage:	-20°C (protect from light & moisture)
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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