ZNF385A (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 1101 Sequence: atgcagcccc cactggacct caagcagatc ctgcccttcc cactcgagcc agcccctacc cttggcctct tcagcaacta cagcaccatg gaccctgtgc agaaggctgt gctctcccac acttttgggg gacccttgct caagaccaag cggcccgtca tttcctgtaa tatctgtcaa atccgcttca attctcagag ccaggctgag gcgcactaca aaggtaatcg ccacgcccga cgagtcaaag gcattgaggc tgccaagacc agaggcaggg agcctggcgt ccgagaacct ggagatccag ctcccccagg cagcacccca acaaatgggg atggtgtagc accccgtcca gtttccatgg agaatggact ggggccagcc ccaggatccc cagagaaaca gcctggctcc ccatcccctc ccagcattcc ggagactggt cagggtgtaa ccaagggtga aggggggact ccagccccgg cttccttgcc tgggggtagc aaggaagagg aggagaaagc caagcggctg ctctactgtg ctctgtgcaa ggtggctgtg aactccctgt cccagcttga ggcacataac aaaggtacta agcacaagac aattctggag gcccgaagtg ggctcgggcc catcaaagct taccctcggc tggggcctcc caccccgggg gaaccagagg ctcctgccca ggaccgaact ttccactgtg agatctgcaa tgtcaaggtc aactcggagg tccaactgaa acagcacatc tccagccggc ggcaccgaga cggcgtggcc gggaagccca acccactact gagccgtcac aagaagtcta ggggcgccgg ggagctggcg ggcacgctga ctttctccaa ggagctgccc aagtccctgg cgggcggcct gctccccagc cccctggcgg tggctgcagt gatggcagcg gcagcaggct cgccgctgtc cctgcgcccg gctccagccg cacctcttct ccagggaccg ccgatcactc accctctgct tcacccggcc cccggaccca tccgaactgc gcacggaccc atcctcttct ccccgtactg Protein function: RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'- UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell- cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. [The UniProt Consortium]