UBE2B (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 459 Sequence: atgtcgaccc cggcccggag gaggctcatg cgggatttca agcggttaca agaggaccca cctgtgggtg tcagtggcgc accatctgaa aacaacatca tgcagtggaa tgcagttata tttggaccag aagggacacc ttttgaagat ggtactttta aactagtaat agaattttct gaagaatatc caaataaacc accaactgtt aggtttttat ccaaaatgtt tcatccaaat gtgtatgctg atggtagcat atgtttagat atccttcaga atcgatggag tccaacatat gatgtatctt ctatcttaac atcaattcag tctctgctgg atgaaccgaa tcctaacagt ccagccaata gccaggcagc acagctttat caggaaaaca aacgagaata tgagaaaaga gtttcggcca ttgttgaaca aagctggaat Protein function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys- 120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA- associated PCNA on 'Lys-164'. May be involved in neurite outgrowth. [The UniProt Consortium]