TRPM4 (Vector pUC, Accession No. BC132727)

Length: 3645 Sequence: atggtggtgc cggagaagga gcagagctgg atccccaaga tcttcaagaa gaagacctgc acgacgttca tagttgactc cacagatccg ggagggacct tgtgccagtg tgggcgcccc cggaccgccc accccgcagt ggccatggag gatgccttcg gggcagccgt ggtgaccgtg tgggacagcg atgcacacac cacggagaag cccaccgatg cctacggaga gctggacttc acgggggccg gccgcaagca cagcaatttc ctccggctct ctgaccgaac ggatccagct gcagtttata gtctggtcac acgcacatgg ggcttccgtg ccccgaacct ggtggtgtca gtgctggggg gatcgggggg ccccgtcctc cagacctggc tgcaggacct gctgcgtcgt gggctggtgc gggctgccca gagcacagga gcctggattg tcactggggg tctgcacacg ggcatcggcc ggcatgttgg tgtggctgta cgggaccatc agatggccag cactgggggc accaaggtgg tggccatggg tgtggccccc tggggtgtgg tccggaatag agacaccctc atcaacccca agggctcgtt ccctgcgagg taccggtggc gcggtgaccc ggaggacggg gtccagtttc ccctggacta caactactcg gccttcttcc tggtggacga cggcacacac ggctgcctgg ggggcgagaa ccgcttccgc ttgcgcctgg agtcctacat ctcacagcag aagacgggcg tgggagggac tggaattgac atccctgtcc tgctcctcct gattgatggt gatgagaaga tgttgacgcg aatagagaac gccacccagg ctcagctccc atgtctcctc gtggctggct cagggggagc tgcggactgc ctggcggaga ccctggaaga cactctggcc ccagggagtg ggggagccag gcaaggcgaa gcccgagatc gaatcaggcg tttctttccc aaaggggacc ttgaggtcct gcaggcccag gtggagagga ttatgacccg gaaggagctc ctgacagtct attcttctga ggatgggtct gaggaattcg agaccatagt tttgaaggcc cttgtgaagg cctgtgggag ctcggaggcc tcagcctacc tggatgagct gcgtttggct gtggcttgga accgcgtgga cattgcccag agtgaactct ttcgggggga catccaatgg cggtccttcc atctcgaagc ttccctcatg gacgccctgc tgaatgaccg gcctgagttc gtgcgcttgc tcatttccca cggcctcagc ctgggccact tcctgacccc gatgcgcctg gcccaactct acagcgcggc gccctccaac tcgctcatcc gcaacctttt ggaccaggcg tcccacagcg caggcaccaa agccccagcc ctaaaagggg gagctgcgga gctccggccc cctgacgtgg ggcatgtgct gaggatgctg ctggggaaga tgtgcgcgcc gaggtacccc tccgggggcg cctgggaccc tcacccaggc cagggcttcg gggagagcat gtatctgctc tcggacaagg ccacctcgcc gctctcgctg gatgctggcc tcgggcaggc cccctggagc gacctgcttc tttgggcact gttgctgaac agggcacaga tggccatgta cttctgggag atgggttcca atgcagtttc ctcagctctt ggggcctgtt tgctgctccg ggtgatggca cgcctggagc ctgacgctga ggaggcagca cggaggaaag acctggcgtt caagtttgag gggatgggcg ttgacctctt tggcgagtgc tatcgcagca gtgaggtgag ggctgcccgc ctcctcctcc gtcgctgccc gctctggggg gatgccactt gcctccagct ggccatgcaa gctgacgccc gtgccttctt tgcccaggat ggggtacagt ctctgctgac acagaagtgg tggggagata tggccagcac tacacccatc tgggccctgg ttctcgcctt cttttgccct ccactcatct acacccgcct catcaccttc aggaaatcag aagaggagcc cacacgggag gagctagagt ttgacatgga tagtgtcatt aatggggaag ggcctgtcgg gacggcggac ccagccgaga agacgccgct gggggtcccg cgccagtcgg gccgtccggg ttgctgcggg ggccgctgcg gggggcgccg gtgcctacgc cgctggttcc acttctgggg cgcgccggtg accatcttca tgggcaacgt ggtcagctac ctgctgttcc tgctgctttt ctcgcgggtg ctgctcgtgg atttccagcc ggcgccgccc ggctccctgg agctgctgct ctatttctgg gctttcacgc tgctgtgcga ggaactgcgc cagggcctga gcggaggcgg gggcagcctc gccagcgggg gccccgggcc tggccatgcc tcactgagcc agcgcctgcg cctctacctc gccgacagct ggaaccagtg cgacctagtg gctctcacct gcttcctcct gggcgtgggc tgccggctga ccccgggttt gtaccacctg ggccgcactg tcctctgcat cgacttcatg gttttcacgg tgcggctgct tcacatcttc acggtcaaca aacagctggg gcccaagatc gtcatcgtga gcaagatgat gaaggacgtg ttcttcttcc tcttcttcct cggcgtgtgg ctggtagcct atggcgtggc cacggagggg ctcctgaggc cacgggacag tgacttccca agtatcctgc gccgcgtctt ctaccgtccc tacctgcaga tcttcgggca gattccccag gaggacatgg acgtggccct catggagcac agcaactgct cgtcggagcc cggcttctgg gcacaccctc ctggggccca ggcgggcacc tgcgtctccc agtatgccaa ctggctggtg gtgctgctcc tcgtcatctt cctgctcgtg gccaacatcc tgctggtcaa cttgctcatt gccatgttca gttacacatt cggcaaagta cagggcaaca gcgatctcta ctggaaggcg cagcgttacc gcctcatccg ggaattccac tctcggcccg cgctggcccc gccctttatc gtcatctccc acttgcgcct cctgctcagg caattgtgca ggcgaccccg gagcccccag ccgtcctccc cggccctcga gcatttccgg gtttaccttt ctaaggaagc cgagcggaag ctgctaacgt gggaatcggt gcataaggag aactttctgc tggcacgcgc tagggacaag cgggagagcg actccgagcg tctgaagcgc acgtcccaga aggtggactt ggcactgaaa cagctgggac acatccgcga gtacgaacag cgcctgaaag tgctggagcg ggaggtccag cagtgtagcc gcgtcctggg gtgggtggcc gaggccctga gccgctctgc cttgctgccc ccaggtgggc cgccaccccc tgacctgcct gggtccaaag Protein function: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:29211723, PubMed:30528822). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation (PubMed:30528822). [The UniProt Consortium]