29 products were found matching "K04979"!

Description: TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 µM. Target: TRP/TRPV Channel. Smiles: OC(=O)c1ccc(Cl)cc1NC(=O)COc1ccccc1Cl. References: 1. Ozhathil L C , Delalande C , Bianchi B , et al. Identification of potent and...

Description: TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion. Target: TRP/TRPV Channel. Smiles: CCN(CCN)Cc1cccc(Br)c1. References: Hilmar BADING, et al. Novel means to modulate nmda receptor-mediated...

9-Phenanthrol is an inhibitor of transient receptor potential melastatin 4 (TRPM4, IC50s = 19.1, 17.1, and 22.8 µM at +40, -40, and -80 mV, respectively, in HEK293 cells expressing the human receptor). It is selective for TRPM4 over TRPM5 at 100 µM. 9-Phenanthrol (100 µM) reduces heart rate in spontaneously beating...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene. It is mapped to 19q13.33. The protein encoded by this gene is a calcium-activated nonselective ion...

In 1X PBS, pH 7.4, with 0.09% sodium azide. The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium...

Protein function: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:29211723). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) >...

Protein function: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:29211723, PubMed:30528822). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) >...

Protein function: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:29211723, PubMed:30528822). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) >...

TRPM4-IN-5 is an inhibitor of transient receptor potential melastatin 4 (TRPM4, IC50 = 1.5 µM in HEK293 cells expressing TRPM4). It is selective for TRPM4 over TRPM5 at 10 µM and TRPM7, TRPM8, transient receptor potential vanilloid 1 (TRPV1), and TRPV6 at 100 µM, as well as a panel of 17 other ion channels and...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse TRPM4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TRPM4. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat TRPM4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat TRPM4. Next,...

Protein function: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:29211723, PubMed:30528822). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) >...