SMPD3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1968 Sequence: ATGGTTTTGT ACACGACCCC CTTTCCTAAC AGCTGTCTGT CCGCCCTGCA CTGTGTGTCC TGGGCCCTTA TCTTTCCATG CTACTGGCTG GTGGACCGGC TCGCTGCCTC CTTCATACCC ACCACCTACG AGAAGCGCCA GCGGGCAGAC GACCCGTGCT GCCTGCAGCT GCTCTGCACT GCCCTCTTCA CGCCCATCTA CCTGGCCCTC CTGGTGGCCT CGCTGCCCTT TGCGTTTCTC GGCTTTCTCT TCTGGTCCCC ACTGCAGTCG GCCCGCCGGC CCTACATCTA TTCACGGCTG GAAGACAAGG GCCTGGCCGG TGGGGCAGCC CTGCTCAGTG AATGGAAGGG CACGGGGCCT GGCAAAAGCT TCTGCTTTGC CACTGCCAAC GTCTGCCTCC TGCCCGACTC ACTCGCCAGG GTCAACAACC TTTTTAACAC CCAAGCGCGG GCCAAGGAGA TCGGGCAGAG AATCCGCAAT GGGGCCGCCC GGCCCCAGAT CAAAATTTAC ATCGACTCCC CCACCAATAC CTCCATCAGC GCCGCTAGCT TCAGCAGCCT GGTGTCACCA CAGGGCGGCG ATGGGGTGGC CCGGGCCGTC CCCGGGAGCA TTAAGAGGAC AGCCTCTGTG GAGTACAAGG GTGACGGTGG GCGGCACCCC GGTGACGAGG CTGCCAACGG CCCAGCCTCT GGGGACCCTG TCGACAGCAG CAGCCCGGAG GATGCCTGCA TCGTGCGCAT CGGTGGCGAG GAGGGCGGCC GGCCACCTGA AGCTGACGAC CCTGTGCCTG GGGGCCAGGC CAGGAACGGA GCTGGCGGGG GCCCAAGGGG CCAGACGCCC AACCATAATC AGCAGGACGG GGATTCAGGG AGCCTGGGCA GCCCCTCGGC CTCCCGGGAG TCCCTGGTGA AGGGGCGAGC TGGGCCAGAC ACCAGTGCCA GCGGGGAGCC AGGTGCCAAC AGCAAGCTCC TGTACAAGGC CTCGGTGGTG AAGAAGGCGG CTGCACGCAG GAGGCGGCAC CCCGACGAGG CCTTCGACCA TGAGGTCTCC GCCTTCTTCC CCGCCAACCT GGACTTCCTG TGCCTGCAGG AGGTGTTTGA CAAGCGAGCA GCCACCAAAT TGAAAGAGCA GCTGCACGGC TACTTCGAGT ACATCCTGTA CGACGTCGGG GTCTACGGCT GCCAGGGCTG CTGCAGCTTC AAGTGTCTCA ACAGCGGCCT CCTCTTTGCC AGCCGCTACC CCATCATGGA CGTGGCCTAT CACTGTTACC CCAACAAGTG TAACGACGAT GCCCTGGCCT CTAAGGGAGC TCTGTTTCTC AAGGTGCAGG TGGGAAGCAC ACCTCAGGAC CAAAGAATCG TCGGGTACAT CGCCTGCACA CACCTGCATG CCCCGCAAGA GGACAGCGCC ATCCGGTGTG GGCAGCTGGA CCTGCTTCAG GACTGGCTGG CTGATTTCCG AAAATCTACC TCCTCGTCCA GCGCAGCCAA CCCCGAGGAG CTGGTGGCAT TTGACGTCGT CTGTGGAGAT TTCAACTTTG ATAACTGCTC CTCTGACGAC AAGCTGGAGC AGCAACACTC CCTGTTCACC CACTACAGGG ACCCCTGCCG CCTGGGGCCT GGTGAGGAGA AGCCGTGGGC CATCGGTACT CTGCTGGACA CGAACGGCCT GTACGATGAG GATGTGTGCA CCCCCGACAA CCTGCAGAAG GTCCTGGAGA GTGAGGAGGG CCGCAGGGAG TACCTGGCGT TTCCCACCAG CAAGAGCTCG GGCCAGAAGG GGCGGAAGGA GCTGCTGAAG GGCAACGGCC GGCGCATCGA CTACATGCTG CATGCAGAGG AGGGGCTGTG CCCAGACTGG AAGGCCGAGG TGGAAGAATT CAGTTTTATC ACCCAGCTGT CCGGCCTGAC GGACCACCTG CCAGTAGCCA TGCGACTGAT GGTGTCTTCG GGGGAGGAGG Protein function: Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:10823942, PubMed:14741383, PubMed:15051724). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions. [The UniProt Consortium]