PIP4K2B (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 846 Sequence: atgtcgtcca actgcaccag caccacggcg gtggcggtgg cgccgctcag cgccagcaag accaagacca agaagaagca tttcgtgtgc cagaaagtga agctattccg ggccagcgag ccgatcctca gcgtcctgat gtggggggtg aaccacacga tcaatgagct gagcaatgtt cctgttcctg tcatgctaat gccagatgac ttcaaagcct acagcaagat caaggtggac aatcatctct tcaataagga gaacctgccc agccgcttta agtttaagga gtattgcccc atggtgttcc gaaaccttcg ggagaggttt ggaattgatg atcaggatta ccagaattca gtgacgcgca gcgcccccat caacagtgac agccagggtc ggtgtggcac gcgtttcctc accacctacg accggcgctt tgtcatcaag actgtgtcca gcgaggacgt ggcggagatg cacaacatct taaagaaata ccaccagttt atagtggagt gtcatggcaa cacgcttttg ccacagttcc tgggcatgta ccgcctgacc gtggatggtg tggaaaccta catggtggtt accaggaacg tgttcagcca tcggctcact gtgcatcgca agtatgacct caagggttct acggttgcca gagaagcgag cgacaaggag aaggccaagg acttgccaac attcaaagac aatgacttcc tcaatgaagg gcagaagctg catgtgggag aggagagtaa aaagaacttc ctggagaaac tgaagcggga cgttgaggag attctcgttc tgtccccagg caggagaatc Protein function: Participates in the biosynthesis of phosphatidylinositol 4,5- bisphosphate (PubMed:9038203, PubMed:26774281). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281). Its GTP-sensing activity is critical for metabolic adaptation (PubMed:26774281). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). [The UniProt Consortium]