PIK3C2A (Vector pUC, Accession No. BC113658)

Length: 5061 Sequence: atggctcaga tatctagcaa cagcggattt aaagaatgtc catcttcaca tccggaacca acaagagcaa aagatgtgga caaagaagaa gcattacaga tggaagcaga ggctttagca aaactgcaaa aggatagaca agtgactgac aatcagagag gctttgagtt gtcaagcagc accagaaaaa aagcacaggt ttataacaag caggattatg atctcatggt gtttcctgaa tcagattccc aaaaaagagc attagatatt gatgtagaaa agctcaccca agctgaactt gagaaactat tgctggatga cagtttcgag actaaaaaaa cacctgtatt accagttact cctattctga gcccttcctt ttcagcacag ctctatttta gacctactat tcagagagga cagtggccac ctggattacc tgggccttcc acttatgctt taccttctat ttatccttct acttacagta aacaggctgc attccaaaat ggcttcaatc caagaatgcc cacttttcca tctacagaac ctatatattt aagtcttccg ggacaatctc catatttctc atatcctttg acacctgcca caccctttca tccacaagga agcttaccta tctatcgtcc agtagtcagt actgacatgg caaaactatt tgacaaaata gctagtacat cagaattttt aaaaaatggg aaagcaagga ctgatttgga gataacagat tcaaaagtca gcaatctaca ggtatctcca aagtctgagg atatcagtaa atttgactgg ttagacttgg atcctctaag taagcctaag gtggataatg tggaggtatt agaccatgag gaagagaaaa atgtttcaag tttgctagca aaggatcctt gggatgctgt tcttcttgaa gagagatcga cagcaaattg tcatcttgaa agaaaggtga atggaaaatc cctttctgtg gcaactgtta caagaagcca gtctttaaat attcgaacaa ctcagcttgc aaaagcccag ggccatatat ctcagaaaga cccaaatggg accagtagtt tgccaactgg aagttctctt cttcaagaag ttgaagtaca gaatgaggag atggcagctt tttgtcgatc cattacaaaa ttgaagacca aatttccata taccaatcac cgcacaaacc caggctattt gttaagtcca gtcacagcgc aaagaaacat atgcggagaa aatgctagtg tgaaggtctc cattgacatt gaaggatttc agctaccagt tacttttacg tgtgatgtga gttctactgt agaaatcatt ataatgcaag ccctttgctg ggtacatgat gacttgaatc aagtagatgt tggcagctat gttctaaaag tttgtggtca agaggaagtg ctgcagaata atcattgcct tggaagtcat gagcatattc aaaactgtcg aaaatgggac acagaaatta gactacaact cttgaccttc agtgcaatgt gtcaaaatct ggcccgaaca gcagaagatg atgaaacacc cgtggattta aacaaacacc tgtatcaaat agaaaaacct tgcaaagaag ccatgacgag acaccctgtt gaagaactct tagattctta tcacaaccaa gtagaactgg ctcttcaaat tgaaaaccaa caccgagcag tagatcaagt aattaaagct gtaagaaaaa tctgtagtgc tttagatggt gtcgagactc ttgccattac agaatcagta aagaagctaa agagagcagt taatcttcca aggagtaaaa ctgctgatgt gacttctttg tttggaggag aagacactag caggagttca actaggggct cacttaatcc tgaaaatcct gttcaagtaa gcataaacca attaactgca gcaatttatg atcttctcag actccatgca aattctggta ggagtcctac agactgtgcc caaagtagca agagtgtcaa ggaagcatgg actacaacag agcagctcca gtttactatt tttgctgctc atggaatttc aagtaattgg gtatcaaatt atgaaaaata ctacttgata tgttcactgt ctcacaatgg aaaggatctt tttaaaccta ttcaatcaaa gaaggttggc acttacaaga atttcttcta tcttattaaa tgggatgaac taatcatttt tcctatccag atatcacaat tgccattaga atcagttctt caccttactc tttttggaat tttaaatcag agcagtggaa gttcccctga ttctaataag cagagaaagg gaccagaagc tttgggcaaa gtttctttac ctctttttga ctttaaacgg tttttaacat gtggaactaa acttctatat ctttggactt catcacatac aaattctgtt cctggaacag ttaccaaaaa aggatatgtc atggaaagaa tagtgctaca ggttgatttt ccttctcctg catttgatat tatttataca actcctcaag ttgacagaag cattatacag caacataact tagaaacact agagaatgat ataaaaggga aacttcttga tattcttcat aaagactcat cacttggact ttctaaagaa gataaagctt ttttatggga gaaacgttat tattgcttca aacacccaaa ttgtcttcct aaaatattag caagcgcccc aaactggaaa tgggttaatc ttgccaaaac ttactcattg cttcaccagt ggcctgcatt gtacccacta attgcattgg aacttcttga ttcaaaattt gctgatcagg aagtaagatc cctagctgtg acctggattg aggccattag tgatgatgag ctaacagatc ttcttccaca gtttgtacaa gctttgaaat atgaaattta cttgaatagt tcattagtgc aattcctttt gtccagggca ttgggaaata tccagatagc acacaattta tattggcttc tcaaagatgc cctgcatgat gtacagttta gtacccgata cgaacatgtt ttgggtgctc tcctgtcagt aggaggaaaa cgacttagag aagaacttct aaaacagacg aaacttgtac agcttttagg aggagtagca gaaaaagtaa ggcaggctag tggatcagcc agacaggttg ttctccaaag aagtatggaa cgagtacagt ccttttttca gaaaaataaa tgccgtctcc ctctcaagcc aagtctagtg gcaaaagaat taaatattaa gtcgtgttcc ttcttcagtt ctaatgctgt ccccctaaaa gtcacaatgg tgaatgctga ccctatggga gaagaaatta atgtcatgtt taaggttggt gaagatcttc ggcaagatat gttagcttta cagatgataa agattatgga taagatctgg cttaaagaag gactagatct gaggatggta attttcaaat gtctctcaac tggcagagat cgaggcatgg tggagctggt tcctgcttcc gataccctca ggaaaatcca agtggaatat ggtgtgacag gatcctttaa agataaacca cttgcagagt ggctaaggaa atacaatccc tctgaagaag aatatgaaaa ggcttcagag aactttatct attcctgtgc tggatgctgt gtagccacct atgttttagg catctgtgat cgacacaatg acaatataat gcttcgaagc acgggacaca tgtttcacat tgactttgga aagtttttgg gacatgcaca gatgtttggc agcttcaaaa gggatcgggc tccttttgtg ctgacctctg atatggcata tgtcattaat gggggtgaaa agcccaccat tcgttttcag ttgtttgtgg acctctgctg tcaggcctac aacttgataa gaaagcagac aaaccttttt cttaacctcc tttcactgat gattccttca gggttaccag aacttacaag tattcaagat ttgaaatacg ttagagatgc acttcaaccc caaactacag acgcagaagc tacaattttc tttactaggc ttattgaatc aagtttggga agcattgcca caaagtttaa cttcttcatt cacaaccttg ctcagcttcg tttttctggt cttccttcta atgatgagcc catcctttca ttttcaccta aaacatactc ctttagacaa gatggtcgaa tcaaggaagt ctctgttttt acatatcata agaaatacaa cccagataaa cattatattt atgtagtccg aattttgagg gaaggacaga ttgaaccatc atttgtcttc cgaacatttg acgaatttca ggaacttcac aataagctca gtattatttt tccactttgg aagttaccag gctttcctaa taggatggtt ctaggaagaa cacacataaa agatgtagca gccaaaagga aaattgagtt aaacagttac ttacagagtt tgatgaatgc ttcaacggat gtagcagagt gtgatcttgt ttgtactttc ttccaccctt tacttcgtga tgagaaagct gaagggatag ctaggtctgc agatgcaggt tccttcagtc ctactccagg ccaaatagga ggagctgtga aattatccat ctcttaccga aatggtactc ttttcatcat ggtgatgcat atcaaagatc ttgttactga agatggagct gacccaaatc catatgtcaa aacataccta cttccagata accacaaaac atccaaacgt aaaaccaaaa tttcacgaaa aacgaggaat ccgacattca atgaaatgct tgtatacagt ggatatagca aagaaaccct aagacagcga gaacttcaac taagtgtact cagtgcagaa tctctgcggg agaatttttt cttgggtgga gtaaccctgc ctttgaaaga tttcaacttg agcaaagaga cggttaaatg gtatcagctg actgcggcaa catacttgta Protein function: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). [The UniProt Consortium]