80 products were found matching "K00923"!

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. PIK3C2A antibody detects Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide, a lipid kinase that regulates membrane trafficking, signal transduction, and cytoskeletal organization. Encoded by the PIK3C2A gene on...

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. PIK3C2B antibody is used to study Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta, a class II phosphoinositide 3-kinase that generates phosphatidylinositol 3-phosphate and phosphatidylinositol 3,4-bisphosphate to...

Roginolisib is an inhibitor of PI3Kdelta (IC50 = 0. µM). It is selective for PI3Kdelta over PI3Kalpha, PI3Kbeta, PI3Kgamma, VPS34, and PI3KC2beta (IC50s = 0. 1. 10. 5. and 5. µM, respectively). Roginolisib inhibits the growth of SU-DHL-6 B cell lymphoma cells that endogenously express PI3Kdelta (GI50 = 0. µM) but...

Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kalpha, beta, and delta are class 1A enzymes composed of p110 and p85 subunits, whereas PI3Kgamma is a class 1B PI3K composed of a p110...

17beta-hydroxy Wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM). 17beta-hydroxy Wortmannin inhibits recombinant PI3K and mTOR (IC50 = 2.7 and 193 nM, respectively) and prevents the growth...

Viridiol is a fungal steroid that demonstrates phytotoxic activity. It is a metabolite of the fungistatic compound, viridin. Both viridin and viridiol are reported to inhibit PI3K.Formal Name: 1beta,3beta-dihydroxy-2beta-methoxy-18-norandrosta-5,8,11,13-tetraeno[6,5,4-bc]furan-7,17-dione. CAS Number: 23820-80-6....

Protein function: Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades. [The UniProt Consortium]

Protein function: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Phosphoinositide-3-kinase, class 2, alpha Protein function: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second...

PF-4989216 is an orally bioavailable broad-spectrum PI3K inhibitor (IC50s = 2, 142, 65, 1, and 110 nM for p110alpha, p110beta, p110gamma, p110delta, and VPS34, respectively). It inhibits the cell viability of small-cell lung cancer (SCLC) cells with a mutation in PIK3CA, blocking PI3K downstream signaling and...

PIK3C2G Antibody is a IgG polyclonal antibody from Assay Genie with reactivity against Human and for use in ELISA, WB applications. PIK3C2G Antibody is a high quality polyclonal antibody for research use only.. Protein function: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol...

Protein function: Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:9830063, PubMed:11533253). Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063). May be involved in EGF and PDGF signaling cascades (PubMed:10805725). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH...