LRRC8E (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1335 Sequence: atgggggaca ttcctgacgt caagaatgac ttcgccttca tgctgcacct catcgatcag tacgactccc tctactccaa gcgcttcgcc gtcttcctgt ccgaggtcag cgaaagccgt ctaaagcagc tcaatctcaa ccacgagtgg acgcccgaga agcttcgaca gaagctgcag cgcaatgccg cgggccggct ggagctggcc ctctgcatgc tgccgggtct gcccgacacc gtctttgagc tcagtgaggt ggagtcactc aggctggagg ccatctgcga tatcaccttc cccccggggc tgtcacagct ggtgcacttg caggagctca gcttgctcca ctcgcccgcc aggctaccct tctccttgca ggtcttcctg cgggaccacc tgaaggtgat gcgcgtcaaa tgcgaggagc tccgcgaggt gccgctttgg gtgtttgggc tgcggggctt ggaggagctg cacctggagg ggcttttccc ccaggagcta gctcgggcag ccaccctgga gagcctccgg gagctgaagc agctcaaggt gttgtccctc cggagcaacg ccgggaaggt gccagccagt gtgaccgacg ttgctggcca cctgcagagg ctcagcctgc acaacgatgg ggcccgtctg gttgccctga acagcctcaa gaagctggcg gcattgcggg agctggagct ggtggcctgc gggctggagc gcatccccca tgcagtgttc agcctgggtg cgctgcagga acttgacctc aaggacaacc acctgcgctc catcgaggaa atcctcagct tccagcactg ccggaagctg gtcacgctca ggctgtggca caaccagatc gcctacgtcc ctgagcacgt gcggaagctc aggagcctgg agcagctcta cctcagctac aacaagctgg agaccctgcc ctcccagctc ggcctgtgct caggcctccg tctgctggat gtgtcccaca atgggctaca ctccctgcca cccgaggtgg gcctcctgca gaacctacag cacctggccc tctcctacaa tgccctggag gccctgcccg aagagctctt cttctgccgc aagctgcgga cgttgcttct gggcgacaac cagctgagcc agctctcgcc ccacgtgggt gccctcagag ccctcagccg cctggagctc aaaggcaacc gcttagaggc gctgccagaa gaacttggca actgtggggg gctcaagaag gcggggctcc tggtggaaga cacgctttac cagggtctgc cggcagaagt gcgggacaag atggaggagg Protein function: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E), channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). [The UniProt Consortium]