LRRC8D (Vector pUC, Accession No. BC024159)

Length: 2577 Sequence: atgtttaccc ttgcggaagt tgcatcactt aatgacattc agccaactta ccgaatcctg aaaccatggt gggatgtgtt tatggattac ctagctgttg ttatgttaat ggtagccatc tttgcaggaa ccatgcaact taccaaagat caggtggtct gtttgccagt attgccatct cctgtaaatt caaaggcaca tacaccacca ggaaatgccg aggtcaccac caacatccca aagatggaag cagccaccaa ccaagaccaa gatgggcgga caacaaacga catttccttt gggacatctg ctgtgacacc tgacatacct ctcagagcca catatcctcg cacagatttc gcacttccaa atcaggaggc aaagaaagag aagaaagatc caacaggtcg aaaaacaaac ttggattttc agcaatatgt atttattaat caaatgtgtt accatctggc ccttccgtgg tattctaagt actttccata cctagctctt atacatacta ttattctcat ggtcagtagc aacttttggt tcaaatatcc caaaacatgc tcaaaagtag aacattttgt ttcaatatta ggaaagtgct ttgaatcccc ttggacgaca aaagcgttgt ctgagacagc atgcgaagac tcagaggaaa acaagcagag aataacaggt gcccagactc taccaaagca tgtttctacc agcagtgatg aagggagccc cagtgccagt acaccaatga tcaataaaac tggctttaaa ttttcagctg agaagcctgt gattgaagtt cccagcatga caatcctgga taaaaaggat ggagagcagg ccaaagccct gtttgagaaa gtgaggaagt tccgtgccca tgtggaagat agtgacttga tctataaact ctatgtggtc caaacagtta tcaaaacagc caagttcatt tttattctct gctatacagc gaactttgtc aacgcaatca gctttgaaca cgtctgcaag cccaaagttg agcatctgat tggttatgag gtatttgagt gcacccacaa tatggcttac atgttgaaaa agcttctcat cagttacata tccattattt gtgtttatgg ctttatctgc ctctacactc tcttctggtt attcaggata cctttgaagg aatattcttt cgaaaaagtc agagaagaga gcagttttag tgacattcca gatgtcaaaa acgattttgc gttccttctt cacatggtag accagtatga ccagctatat tccaagcgtt ttggtgtgtt cttgtcagaa gttagtgaaa ataaacttag ggaaattagt ttgaaccatg agtggacatt tgaaaaactc aggcagcaca tttcacgcaa cgcccaggac aagcaggagt tgcatctgtt catgctgtcg ggggtgcccg atgctgtctt tgacctcaca gacctggatg tgctaaagct tgaactaatt ccagaagcta aaattcctgc taagatttct caaatgacta acctccaaga gctccacctc tgccactgcc ctgcaaaagt tgaacagact gcttttagct ttcttcgcga tcacttgaga tgccttcacg tgaagttcac tgatgtggct gaaattcctg cctgggtgta tttgctcaaa aaccttcgag agttgtactt aataggcaat ttgaactctg aaaacaataa gatgatagga cttgaatctc tccgagagtt gcggcacctt aagattctcc acgtgaagag caatttgacc aaagttccct ccaacattac agatgtggct ccacatctta caaagttagt cattcataat gacggcacta aactcttggt actgaacagc cttaagaaaa tgatgaatgt cgctgagctg gaactccaga actgtgagct agagagaatc ccacatgcta ttttcagcct ctctaattta caggaactgg atttaaagtc caataacatt cgcacaattg aggaaatcat cagtttccag catttaaaac gactgacttg tttaaaatta tggcataaca aaattgttac tattcctccc tctattaccc atgtcaaaaa cttggagtca ctttatttct ctaacaacaa gctcgaatcc ttaccagtgg cagtatttag tttacagaaa ctcagatgct tagatgtgag ctacaacaac atttcaatga ttccaataga aataggattg cttcagaacc tgcagcattt gcatatcact gggaacaaag tggacattct gccaaaacaa ttgtttaaat gcataaagtt gaggactttg aatctgggac agaactgcat cacctcactc ccagagaaag ttggtcagct ctcccagctc actcagctgg agctgaaggg gaactgcttg gaccgcctgc cagcccagct gggccagtgt cggatgctca agaaaagcgg gcttgttgtg gaagatcacc tttttgatac cctgccactc gaagtcaaag aggcattgaa tcaagacata aatattccct ttgcaaatgg Protein function: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E), channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309). [The UniProt Consortium]