LRRC8C (Vector pUC, Accession No. BC113973)

Length: 2412 Sequence: ATGATTCCCG TGACAGAATT CCGGCAGTTC TCTGAGCAGC AGCCTGCCTT CCGAGTGCTG AAGCCATGGT GGGATGTGTT TACCGATTAC CTCTCAGTAG CCATGCTCAT GATCGGCGTG TTTGGATGTA CTTTACAGGT CATGCAAGAC AAGATAATCT GCCTTCCGAA AAGAGTGCAG CCTGCTCAGA ACCACTCTTC CCTTTCGAAT GTCTCTCAAG CAGTTGCCAG TACCACTCCA CTGCCTCCAC CTAAACCATC TCCTGCTAAC CCCATCACTG TGGAAATGAA AGGCCTGAAG ACAGATTTGG ACCTTCAGCA GTACAGCTTT ATAAATCAGA TGTGTTATGA GCGAGCCCTC CACTGGTATG CCAAGTATTT CCCTTACCTT GTCCTCATCC ATACCCTGGT CTTTATGCTC TGCAGTAACT TTTGGTTCAA ATTCCCTGGT TCCAGCTCCA AAATAGAACA TTTCATCTCC ATTCTGGGGA AGTGTTTTGA CTCTCCTTGG ACCACACGGG CTTTATCTGA AGTGTCTGGG GAGGACTCAG AAGAAAAGGA CAACAGGAAG AACAACATGA ACAGGTCCAA CACCATCCAA TCTGGTCCAG AAGGCAGCCT GGTCAACTCT CAGTCTTTAA AGTCCATTCC TGAGAAGTTT GTAGTTGATA AATCCACTGC AGGGGCTCTG GATAAAAAGG AAGGTGAGCA GGCTAAGGCC TTATTTGAGA AGGTGAAGAA GTTCAGGCTG CATGTGGAAG AAGGTGATAT TCTATATGCC ATGTATGTTC GCCAGACTGT ACTTAAAGTT ATCAAATTCC TAATCATCAT TGCATATAAT AGTGCTCTGG TTTCCAAGGT CCAGTTTACA GTGGACTGTA ATGTGGACAT TCAGGACATG ACTGGATATA AAAACTTTTC TTGCAATCAT ACCATGGCAC ACTTGTTCTC AAAACTGTCC TTTTGCTATC TGTGCTTTGT TAGTATCTAT GGATTGACGT GCCTTTATAC CTTATACTGG CTGTTCTACC GTTCTCTACG GGAATATTCC TTTGAGTATG TCCGTCAGGA GACTGGAATT GATGATATTC CAGATGTGAA AAATGACTTT GCTTTTATGC TTCATATGAT AGATCAGTAT GACCCTCTCT ATTCCAAGAG ATTTGCAGTG TTCCTGTCTG AAGTCAGTGA AAACAAATTA AAGCAGCTGA ACTTAAATAA CGAATGGACT CCTGATAAAC TGAGGCAGAA GCTACAGACA AATGCCCATA ATCGACTGGA ATTGCCTCTT ATCATGCTCT CTGGCCTTCC AGACACTGTT TTTGAAATCA CAGAGTTGCA ATCTCTAAAA CTTGAAATCA TTAAGAACGT AATGATACCA GCCACCATTG CACAGCTAGA CAATCTTCAA GAGCTCTCTC TGCACCAGTG TTCTGTCAAA ATCCACAGTG CGGCGCTCTC TTTCCTGAAG GAAAACCTCA AGGTCTTGAG CGTCAAGTTT GATGACATGA GGGAACTCCC CCCCTGGATG TATGGGCTCC GAAATCTGGA AGAGCTGTAC CTAGTTGGCT CTCTAAGTCA TGATATTTCC AGAAATGTCA CCCTTGAGTC TCTGCGGGAT CTCAAAAGCC TTAAAATTCT CTCTATCAAA AGCAACGTTT CCAAAATCCC TCAGGCAGTG GTTGATGTTT CCAGCCATCT CCAGAAGATG TGCATACATA ATGATGGCAC CAAGCTGGTG ATGCTCAACA ACTTAAAGAA GATGACCAAT CTGACAGAGC TGGAGCTGGT CCACTGTGAC CTGGAGCGTA TTCCTCATGC TGTGTTCAGC CTACTCAGCC TCCAGGAATT GGACCTGAAG GAAAACAATC TGAAATCTAT AGAAGAAATC GTTAGCTTTC AGCACTTAAG AAAGTTGACA GTGCTAAAAC TGTGGCATAA CAGCATCACC TACATCCCAG AGCATATAAA GAAACTCACC AGCCTGGAAC GCCTGTCCTT TAGTCACAAT AAAATAGAGG TGCTGCCTTC CCACCTCTTC CTATGCAACA AGATCCGATA CTTGGACTTA TCGTACAATG ACATTCGATT TATCCCCCCT GAAATTGGAG TTCTACAAAG TTTACAGTAT TTTTCCATCA CATGTAACAA AGTGGAAAGC CTTCCAGATG AACTCTACTT CTGCAAGAAA CTTAAAACTC TGAAGATTGG AAAAAACAGC CTATCTGTAC TTTCACCGAA AATTGGAAAT TTGCTATTTC TTTCCTACTT AGATGTAAAA GGTAATCACT TTGAAATCCT CCCTCCTGAA CTGGGTGACT GTCGGGCTCT GAAGCGAGCT GGTTTAGTTG TAGAAGATGC TCTGTTTGAA ACTCTGCCTT CTGACGTCCG GGAGCAAATG AAAACAGAAT Protein function: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E), channel characteristics depend on the precise subunit composition. [The UniProt Consortium]