HSD17B3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 933 Sequence: atgggggacg tcctggaaca gttcttcatc ctcacagggc tgctggtgtg cctggcctgc ctggcgaagt gcgtgagatt ctccagatgt gttttactga actactggaa agttttgcca aagtctttct tgcggtcaat gggacagtgg gcagtgatca ctggagcagg cgatggaatt gggaaagcgt actcgttcga gctagcaaaa cgtggactca atgttgtcct tattagccgg acgctggaaa aactagaggc cattgccaca gagatcgagc ggactacagg gaggagtgtg aagattatac aagcagattt tacaaaagat gacatctacg agcatattaa agaaaaactt gcaggcttag aaattggaat tttagtcaac aatgtcggaa tgcttccaaa ccttctccca agccatttcc tgaacgcacc ggatgaaatc cagagcctca tccattgtaa catcacctcc gtagtcaaga tgacacagct aattctgaaa catatggaat caaggcagaa aggtctcatc ctgaacattt cttctgggat agccctgttt ccttggcctc tctactccat gtactcagct tccaaggcgt ttgtgtgcgc attttccaag gccctgcaag aggaatataa agcaaaagaa gtcatcatcc aggtgctgac cccatatgct gtctcgactg caatgacaaa gtatctaaat acaaatgtga taaccaagac tgctgatgag tttgtcaaag agtcattgaa ttatgtcaca attggaggtg aaacctgtgg ctgccttgcc catgaaatct tggcgggctt tctgagcctg atcccggcct gggccttcta cagcggtgcc ttccaaaggc tgctcctgac acactatgtg gcatacctga agctcaacac caaggtcagg Protein function: Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH (PubMed:26545797, PubMed:8075637, PubMed:16216911). Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (PubMed:16216911). [The UniProt Consortium]