GPR183 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1086 Sequence: atggatatac aaatggcaaa caattttact ccgccctctg caactcctca gggaaatgac tgtgacctct atgcacatca cagcacggcc aggatagtaa tgcctctgca ttacagcctc gtcttcatca ttgggctcgt gggaaactta ctagccttgg tcgtcattgt tcaaaacagg aaaaaaatca actctaccac cctctattca acaaatttgg tgatttctga tatacttttt accaccgctt tgcctacacg aatagcctac tatgcaatgg gctttgactg gagaatcgga gatgccttgt gtaggataac tgcgctagtg ttttacatca acacatatgc aggtgtgaac tttatgacct gcctgagtat tgaccgcttc attgctgtgg tgcaccctct acgctacaac aagataaaaa ggattgaaca tgcaaaaggc gtgtgcatat ttgtctggat tctagtattt gctcagacac tcccactcct catcaaccct atgtcaaagc aggaggctga aaggattaca tgcatggagt atccaaactt tgaagaaact aaatctcttc cctggattct gcttggggca tgtttcatag gatatgtact tccacttata atcattctca tctgctattc tcagatctgc tgcaaactct tcagaactgc caaacaaaac ccactcactg agaaatctgg tgtaaacaaa aaggctctca acacaattat tcttattatt gttgtgtttg ttctctgttt cacaccttac catgttgcaa ttattcaaca tatgattaag aagcttcgtt tctctaattt cctggaatgt agccaaagac attcgttcca gatttctctg cactttacag tatgcctgat gaacttcaat tgctgcatgg acccttttat ctacttcttt gcatgtaaag ggtataagag aaaggttatg aggatgctga aacggcaagt cagtgtatcg atttctagtg ctgtgaagtc agcccctgaa gaaaattcac gtgaaatgac agaaacgcag atgatgatac attccaagtc ttcaaatgga Protein function: G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes. Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212, PubMed:22875855, PubMed:22930711). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient. Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses. Collaborates with CXCR5 to mediate B-cell migration, probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:22913878). Also acts as a chemotactic receptor for some T-cells upon binding to 7- alpha,25-OHC ligand. Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle- T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand. Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels. Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897). Promotes osteoclast precursor migration to bone surfaces. Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)- alpha (PubMed:21673108, PubMed:25297897). Signals constitutively also via MAPK1/3 (ERK1/2). [The UniProt Consortium]