21 products were found matching "K04305"!

An EBI2 inverse agonist, inhibits CREB activity in a reporter assay using HEK293 cells transiently transfected with EBI2 and Gqi4myr (IC50 = 53.6 nM), inhibits antibody-induced proliferation of B cells isolated from transgenic mice overexpressing human EBI2 from 0.001-1 µM. SMILES:...

GPR183 (also known as Epstein-Barr virus-induced gene 2) is an orphan G protein-coupled receptor (GPCR) that is highly expressed in spleen and is required for humoral immune responses, including B cell migration and T cell-dependent antibody production. 7alpha,25-dihydroxy Cholesterol (7alpha,25-DHC) is a potent...

An active metabolite of cholesterol, activates EBI2/GPR183 in a GTPgammaS assay (EC50 = 221 nM) but does not bind to EBI2 in CHO cell membranes expressing the human receptor in a radioligand binding assay (IC50 = 2,632 nM), acts as a cellular chaperone that corrects the localization defect of NPC1I1061T in HEK293...

Epstein-Barr virus-induced G protein-coupled receptor 2 (EBI2, also known as GPR183) is an oxysterol receptor involved in B cell migration and function. NIBR189 is an antagonist of EBI2 (IC50s = 11 and 15 nM for human and mouse receptors, respectively). It is selective for EBI2 over a panel of other receptors,...

Description: 7alpha,25-dihydroxycholesterol (7alpha,25-OHC) is a potent and selective agonist, as well as an endogenous ligand, of the orphan GPCR receptor EBI2 (GPR183). It serves as a chemokine directing the migration of B cells, T cells, and dendritic cells and exhibits high potency in activating EBI2 (EC50=140...

Description: NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor (IC50 of 11 and 15 nM for human and mouse EBI2 receptors, respectively). Target: EBI2/GPR183. Smiles: COc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)\C=C\c1ccc(Br)cc1. References: Gessier F , Preuss I , Yin H , et al. Identification and...

An EBI2 antagonist (IC50 = 1.03 nM), inhibits RS11846 cell chemotaxis (IC50 = 4.533 nM). Formulation: A solid. InChI: InChI=1S/C20H20BrClN2O/c21-18-6-1-16(2-7-18)5-10-20(25)24-13-11-23(12-14-24)15-17-3-8-19(22)9-4-17/h1-10H,11-15H2/b10-5+. InChIKey: NXTNVQJKGHAGAX-BJMVGYQFSA-N. SMILES:...

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....

Protein function: G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes. Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212,...

Protein function: G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes. Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212,...

This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid...

Length: 1086 Sequence: atggatatac aaatggcaaa caattttact ccgccctctg caactcctca gggaaatgac tgtgacctct atgcacatca cagcacggcc aggatagtaa tgcctctgca ttacagcctc gtcttcatca ttgggctcgt gggaaactta ctagccttgg tcgtcattgt tcaaaacagg aaaaaaatca actctaccac cctctattca acaaatttgg tgatttctga tatacttttt accaccgctt tgcctacacg...