CLCN2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1164 Sequence: atggctgcct ggttcccaga tggaattcat acggacagca gcacctaccg gattgtgcct gggggctacg ctgtggtcgg ggcagctgcg ctggcaggag cggtgacaca cacagtgtcc acggctgtga tcgtgttcga gctcacaggc cagattgccc acatcctgcc tgtcatgatc gtcgtcatcc tggccaacgc tgtcgcccag agtctgcagc cctccctcta tgacagcatc atccgaatca agaaactgcc ctacctgcct gagctcggct ggggccgcca ccagcagtac cgggtgcgtg tggaggacat catggtgcgg gatgttcccc atgtggccct cagctgcacc ttccgggacc tgcgtttggc actgcacagg accaagggcc gaatgctggc cctagtggag tcccctgagt ccatgattct gctgggctcc atcgagcgtt cacaggtggt ggcattgttg ggggcccagc tgagcccagc ccgccggcgg cagcacatgc aggagcgcag agccacccag acctctccac tatctgatca ggagggtccc cctacccctg aggcttctgt ctgcttccag gtgaacacag aagactcagc cttcccagca gcccgggggg agacccacaa gcccctaaag cctgcactca agagggggcc cagtgtcacc aggaacctcg gagagagtcc cacagggagc gcagagtcgg caggcatcgc cctccggagc ctcttctgtg gcagtccacc ccctgaggct gcttcggaga agttggaatc ctgtgagaag cgcaagctga agcgtgtccg aatctccctg gcaagtgacg cggacctgga aggcgagatg agccctgaag agactcacac tatcttctca ctgctgggag tggaccatgc ttatgtcacc agtattggca gactcattgg aatcgttact ctaaaggagc tccggaaggc catcgagggc tctgtcacag cacagggtgt gaaagtccgg ccgcccctcg ccagcttccg agacagtgcc accagcagca gtgacacgga gaccactgag gtgcatgcac tctgggggcc ccactcccgt catggcctcc cccgggaggg cagcccttcc gacagcgacg acaaatgcca Protein function: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage- gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (PubMed:29403011, PubMed:29403012). [The UniProt Consortium]