BBS2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 2166 Sequence: atgctgctgc ctgtgttcac cctgaaactg cgccacaaaa tcagcccccg aatggtggcc atagggcgct acgacgggac tcacccgtgc ctggcggccg ccacccaaac gggcaaggtt tttattcata atcctcatac acggaaccag catgtcagtg catccagggt cttccagagc cccctggaat ctgatgtttc tcttctcaac attaaccagg cagtcagctg tctgactgca ggcgtattga accctgagct tggctatgat gcccttttag tggggacaca gactaatctt ttggcttatg atgtctacaa taattcggat ttgttctaca gagaggtagc agatggggca aatgtagttg tgctggggac attgggagac atttcttccc ctcttgcgat tattggtggc aattgtgctc tgcaaggttt caatcatgaa ggaagtgatc tcttttggac ggttactgga gacaatgtta attccttggc cttgtgtgac tttgatggtg atggaaagaa agagcttctt gttggatctg aggattttga tatccgagtt tttaaggaag atgagattgt ggcagaaatg acagaaacag agatagtcac ctctctttgt cccatgtatg gcagtcgatt tggttatgcc ctttccaatg gcacagttgg agtttatgac aaaacatccc gatactggag aattaaatcg aaaaatcatg ccatgagcat tcatgctttt gaccttaatt ctgatggagt gaatgaactg ataactggtt ggtccaatgg gaaggttgat gctcgaagtg accgaactgg ggaggtcatc tttaaggaca atttttcttc tgcaattgcc ggtgtggtag agggagatta ccggatggat ggccacatac agttaatctg ctgctcagtg gatggggaaa tccggggcta cctgcctggc acggctgaga tgaggggcaa cctcatggac accagtgcag agcaggacct gatccgagag ctgagtcaga agaagcagaa tctgttgctg gaactccgta actatgagga aaatgccaag gctgaattgg ccagtccact gaacgaggct gatgggcatc ggggcataat cccagccaat accaggctcc acaccacgct ctcagtcagc ctggggaatg agacccaaac tgctcataca gaattacgca tttccacttc taatgacacc atcatccgag cagtattgat ttttgcagaa ggaattttta caggtgaaag ccacgtggta catcccagca ttcacaacct ctccagttcc atctgcatcc ctattgtgcc tcccaaagat gtccctgtgg atctgcactt gaaggcattc gtgggttaca gaagcagcac ccagtttcat gtatttgaat cgacaagaca gctccctcga ttctccatgt atgcgctgac cagcctggac cctgccagtg agccaatcag ttatgttaac tttaccattg cagaacgggc acagagggtt gttgtatggc tcggtcagaa ctttctgtta ccagaagaca ctcacattca gaatgctcca tttcaagtgt gtttcacatc tttacggaat ggcggccacc tgcatataaa aataaaactt agtggagaga tcactataaa tactgatgat attgatttgg ctggtgatat catccagtca atggcatcat tttttgctat tgaagacctt caagtagaag cggattttcc tgtctatttt gaggaattac gaaaggtgct agttaaggtg gatgaatatc attcagtgca tcagaagctc agtgctgata tggctgatca ttctaatttg atccgaagtt tgctggtcgg agctgaggat gctcgtctga tgagggacat gaaaacaatg aagagtcgtt atatggaact ctatgacctt aatagagact tgctaaatgg atataaaatt cgctgtaaca atcacacaga gctgttggga aacctcaaag cagtaaatca agcaattcaa agagcaggtc gtctgcgggt tggaaaacca aagaaccagg tgatcactgc ttgtcgggat gcaattcgaa gcaataacat caacacactg ttcaaaatca tgcgagtggg gacagcttct Protein function: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. [The UniProt Consortium]