NS 304-d6

NS 304-d6 is intended for use as an internal standard for the quantification of NS 304 (Cay-10010411) by GC- or LC-MS. NS 304 is an IP receptor agonist and a prodrug form of MRE-269 (Cay-10010412). It binds to the IP receptor (Ki = 260 nM for the human receptor) and induces cAMP accumulation in CHO cells expressing the human IP receptor (EC50 = 177 nM). NS 304 is selective for the IP receptor over DP, EP1-4, FP, and TP receptors (Kis = >10 µM for all). NS 304 inhibits the aggregation of isolated human and monkey but not dog platelet-rich plasma (IC50s = 5. 3. and >100 µM, respectively). It increases femoral skin blood flow in rats when administered at 1 or 3 mg/kg intraduodenally. NS 304 (1 mg/kg) increases survival and decreases right ventricular systolic pressure and hypertrophy in a rat model of pulmonary arterial hypertension induced by monocrotaline (Cay-16666). Formulations containing NS 304 have been used in the treatment of pulmonary arterial hypertension. InChI: InChI=1S/C26H32N4O4S/c1-20(2)30(16-10-11-17-34-19-24(31)29-35(3,32)33)23-18-27-25(21-12-6-4-7-13-21)26(28-23)22-14-8-5-9-15-22/h4-9,12-15,18,20H,10-11,16-17,19H2,1-3H3,(H,29,31)/i1D3,2D3 InChIKey: QXWZQTURMXZVHJ-WFGJKAKNSA-N SMILES: O=C(NS(C)(=O)=O)COCCCCN(C(C([2H])([2H])[2H])C([2H])([2H])[2H])C1=CN=C(C(C2=CC=CC=C2)=N1)C3=CC=CC=C3