Adaptaquin-d4

Adaptaquin-d4 is intended for use as an internal standard for the quantification of adaptaquin (Cay-19720) by GC- or LC-MS. Adaptaquin is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2. IC50 = 2 µM). It stabilizes HIF-1alpha protein and induces expression of the HIF-1-regulated genes EPO and VEGF in SH-SY5Y human neuroblastoma cells. Adaptaquin protects against cell death induced by glutathione depletion in rat primary cortical neurons (IC50 = 0. µM) and reduces glutamate-induced cell death in HT22 cells. In vivo, adaptaquin (30 mg/kg) increases pellet retrieval in the single-pellet reaching task in a rat autologous striatal blood infusion model of intracerebral hemorrhage and normalizes preference for ipsilateral turns in a mouse model of striatal hemorrhage. Formal Name: 7-((4-chlorophenyl-2,3,5,6-d4)((3-hydroxypyridin-2-yl)amino)methyl)quinolin-8-ol. Molecular Formula: C21H12D4ClN3O2. Formula Weight: 381.9. Purity: >99% deuterated forms (d1-d4). Formulation (Request formulation change): A solid. Solubility: DMSO: Soluble. SMILES: OC1=CC=CN=C1NC(C2=C([2H])C([2H])=C(Cl)C([2H])=C2[2H])C3=C(O)C(N=CC=C4)=C4C=C3. InChi Code: InChI=1S/C21H16ClN3O2/c22-15-8-5-14(6-9-15)18(25-21-17(26)4-2-12-24-21)16-10-7-13-3-1-11-23-19(13)20(16)27/h1-12,18,26-27H,(H,24,25)/i5D,6D,8D,9D. InChi Key: KKYHNYRUBSYTCZ-PKHQNOSGSA-N. Storage: -20°C. Stability: > 4 years.