116 products were found matching "K09592"!

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. EGLN1 antibody targets Egl nine homolog 1, encoded by the EGLN1 gene. Egl nine homolog 1, also known as prolyl hydroxylase domain protein 2, is a cytoplasmic and nuclear enzyme that functions as a central oxygen sensor in mammalian cells....

Description: EGLN2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli with N-6xHis-SUMO. The accession number is Q96KS0.

Description: EGLN3 Protein, Human, Recombinant (His) is expressed in E. coli with C-6xHis. The accession number is Q9H6Z9.

Description: EGLN1 Protein, Human, Recombinant (His) is expressed in E. coli. The accession number is Q9GZT9.

Roxadustat is an analog of 2-OG that has been developed as an inhibitor of HIF-PHs. While little has been published regarding the actions of this compound, similar HIF-PH inhibitors suppress HIF degradation and in this way induce erythropoietin expression, promoting erythropoiesis or preventing anemia in vivo.Formal...

Adaptaquin-d4 is intended for use as an internal standard for the quantification of adaptaquin (Cay-19720) by GC- or LC-MS. Adaptaquin is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2. IC50 = 2 µM). It stabilizes HIF-1alpha protein and induces expression of the HIF-1-regulated genes EPO and...

Vadadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) and HIF-PH3 (IC50s = 1.1 and 0.39 micromolar, respectively). It stabilizes HIF-1alpha in mouse hepatocyte nuclear extracts. Vadadustat (50 and 100 mg/kg) increases erythropoietin levels in mouse serum.Formal Name:...

Rabbit Polyclonal EGLN2 Antibody against Human egl-9 family hypoxia inducible factor 2. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000058709: 78%,...

BAY 85-3934 is a pan-inhibitor of hypoxia-inducible factor prolyl hydroxylases (HIF-PH, IC50s = 0.48, 0.28, and 0.45 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It stabilizes HIF-1alpha and HIF-2alpha levels in HeLa cells in a concentration- and time-dependent manner. BAY 85-3934 (50 µM) induces cell-cycle...

Ciclopirox is an iron chelator, antifungal, and anticancer agent. It inhibits the iron-dependent enzyme hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2, IC50 = 1.58 µM), an effect that is reduced in the presence of iron. It stabilizes hypoxia-inducible factor-alpha (HIF-1alpha) under normoxic conditions in...

FG-2216 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2, IC50 = 3.9 micromolar). It has been shown to reversibly stimulate erythropoietin secretion at 100 µM in vitro and to increase hematocrit, red blood cell count, and hemoglobin levels at 50 mg/kg in mice.Formal Name:...

Daprodustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 1 (HIF-PH1), HIF-PH2, and HIF-PH3 (IC50s = 3.5, 22.2, 5.5 nM, respectively). It is selective for HIF-PH1, -2, and -3 over factor-inhibiting HIF (FIH) and collagen prolyl hydroxylase (CP4H, IC50s = 9,800 and >200,000 nM, respectively)....