TC-FPR 43

TC-FPR 43 is an agonist of formyl peptide receptor 1 (FPR1) and FPR2, which was previously known as formyl peptide receptor-like 1 (FPRL1). TC-FPR 43 induces calcium flux in CHO cells expressing human FPR2, Galpha15, and aequorin (EC50 = 0.044 µM) and in CHO-K1 cells expressing either human FPR1, human FPR2, mouse Fpr1, or mouse Fpr2, Galpha16, and aequorin in a concentration-dependent manner. TC-FPR 43 inhibits migration of polymorphonuclear (PMN) neutrophils induced by fMLP (Cay-21495) or IL-8 with IC50 values of 0.64 and 0.24 µM, respectively. It also reduces ear swelling induced by prostaglandin E2 (PGE2, Cay-14010) and leukotriene B4 (LTB4, Cay-20110) in mice when administered at a dose of 50 mg/kg.Formal Name: N-(4-chlorophenyl)-N'-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea. CAS Number: 903895-98-7. Synonyms: FPR Agonist 43. Molecular Formula: C20H21ClN4O2. Formula Weight: 384.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml, DMSO: 1 mg/ml. lambdamax: 247 nm. SMILES: ClC1=CC=C(NC(NC2=C(C(C)C)N(C)N(C3=CC=CC=C3)C2=O)=O)C=C1. InChi Code: InChI=1S/C20H21ClN4O2/c1-13(2)18-17(23-20(27)22-15-11-9-14(21)10-12-15)19(26)25(24(18)3)16-7-5-4-6-8-16/h4-13H,1-3H3,(H2,22,23,27). InChi Key: PAEBEUZTAPIOIO-UHFFFAOYSA-N.