Pranoprofen-13C-d3

Pranoprofen-13C-d3 is intended for use as an internal standard for the quantification of pranoprofen (Cay-17875) by GC- or LC-MS. Pranoprofen is a non-steroidal anti-inflammatory drug (NSAID) and COX-1 inhibitor (IC50 = 3.1 µM). It decreases B. pertussis-induced production of prostaglandin E2 (PGE2, Cay-14010) in isolated rat peritoneal leukocytes (IC50 = 0.39 µM). Ocular application of pranoprofen reduces corneal epithelial damage in a mouse model of corneal alkali burns.Formal Name: alpha-methyl-13C-d3-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid. Synonyms: Pyranoprofen-13C-d3, Y 8004-13C-d3. Molecular Formula: C14[13C]H10D3NO3. Formula Weight: 259.3. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. SMILES: O=C(C([13C]([2H])([2H])[2H])C1=CC=C2OC3=NC=CC=C3CC2=C1)O. InChi Code: InChI=1S/C15H13NO3/c1-9(15(17)18)10-4-5-13-12(7-10)8-11-3-2-6-16-14(11)19-13/h2-7,9H,8H2,1H3,(H,17,18)/i1+1D3. InChi Key: TVQZAMVBTVNYLA-KQORAOOSSA-N.