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PGS-IN-1 is a non-steroidal anti-inflammatory drug (NSAID) and a dual inhibitor of COX and 5-lipoxygenase (5-LO, IC50s = 0.44 and 0.85 µM, respectively). It is selective for 5-LO over 12-LO (IC50 = >100 µM for the rabbit enzyme ). Oral administration of PGS-IN-1 (10 mg/kg per day) inhibits paw swelling and bone damage in a rat model of M. butyricum-induced arthritis.Formal Name: (E)-3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-2(3H)-furanone. CAS Number: 102271-49-8. Synonyms: KME-4, PGS Inhibitor 1, PG Synthetase Inhibitor 1, Prostaglandin Synthetase Inhibitor 1. Molecular Formula: C19H26O3. Formula Weight: 302.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 5 mg/ml. lambdamax: 218, 238, 318 nm. SMILES: CC(C)(C1=C(C(C(C)(C)C)=CC(/C=C2CCOC\2=O)=C1)O)C. InChi Code: InChI=1S/C19H26O3/c1-18(2,3)14-10-12(9-13-7-8-22-17(13)21)11-15(16(14)20)19(4,5)6/h9-11,20H,7-8H2,1-6H3/b13-9+. InChi Key: DFPYHQJPGCODSB-UKTHLTGXSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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