O-Acetyl Salicylhydroxamic Acid

O-Acetyl Salicylhydroxamic Acid (O-ASHA) is an irreversible, non-selective inhibitor of COX-1 and COX-2. Aspirin is the best-studied example of an irreversible COX inhibitor, acting via the acetylation of the active site serine residue 529 in human COX-1. O-ASHA inhibits ovine COX-1 in a time-dependent, irreversible manner with a 50% B/B0 value of approximately 4.5 mM.Formal Name: N-(acetyloxy)-2-hydroxy benzamide. CAS Number: 199854-00-7. Synonyms: AcSHA, O-ASHA. Molecular Formula: C9H9NO4. Formula Weight: 195.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 50 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): .2 mg/ml. SMILES: CC(=O)ONC(=O)c1ccccc1O. InChi Code: InChI=1S/C9H9NO4/c1-6(11)14-10-9(13)7-4-2-3-5-8(7)12/h2-5,12H,1H3,(H,10,13). InChi Key: PCFWLDHLJWUGSU-UHFFFAOYSA-N.