Myriocin

Myriocin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay63150-1 1 mg -

6 - 10 business days*

27.00€
Cay63150-5 5 mg -

6 - 10 business days*

69.00€
Cay63150-10 10 mg -

6 - 10 business days*

113.00€
Cay63150-25 25 mg -

6 - 10 business days*

198.00€
 
Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case... more
Product information "Myriocin"
Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus in a murine model. Formal Name: 2S-amino-3R,4R-dihydroxy-2-(hydroxymethyl)-14-oxo-6E-eicosenoic acid. CAS Number: 35891-70-4. Synonyms: ISP-1, Thermozymocidin. Molecular Formula: C21H39NO6. Formula Weight: 401.5. Purity: >95%. Formulation: A crystalline solid. Solubility: Methanol: 2 mg/ml. SMILES: O=C(CCCCCC)CCCCCC/C=C/C[C@@H](O)[C@H](O)[C@@](C(O)=O)(N)CO. InChi Code: InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1. InChi Key: ZZIKIHCNFWXKDY-GNTQXERDSA-N. Origin: Fungi/Mycelia sterilia.
Keywords: ISP-1, Thermozymocidin, 2S-amino-3R,4R-dihydroxy-2-(hydroxymethyl)-14-oxo-6E-eicosenoic acid
Supplier: Cayman Chemical
Supplier-Nr: 63150

Properties

Application: Serine palmitoyltransferase inhibitor
MW: 401.5 D
Formula: C21H39NO6
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 35891-70-4| Find alternatives
KEGG ID : K00654 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H301
P Phrases: P264, P270, P301+310, P321, P330, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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