91 products were found matching "K00654"!

Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the...

Protein function: Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate,...

Protein function: Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate,...

Sphingolipids play essential roles in various cellular events, including proliferation, differentiation, senescence, apoptosis, and inflammatory responses. Serine palmitoyltransferase (SPT) is the initial and rate-limiting enzyme in the de novo sphingolipid biosynthesis, and thus regulates the level of sphingolipids...

Anti-sRANK Ligand Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with sRANK Ligand from other sources has not been determined. Protein function: Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic...

Anti-SREBF1 antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. SREBF1 antibody is human and mouse reactive. At least three isoforms of SREBF1 are known to exist. SREBF1 antibody is predicted not to cross-react with SREBF2. Protein function: Serine palmitoyltransferase (SPT)....

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Serine palmitoyltransferase, long chain base subunit 1, also known as SPT1, LCB1, is a protein which in humans is encoded by the SPTLC1 gene. Dawkins et al.(2001)noted that the gene maps to chromosome 9q22.1-q22.3. Serine palmitoyltransferase, which consists of...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. SPTLC1 (Serine palmitoyltransferase, long chain base subunit 1), also known as SPT1, LCB1, is a protein which in humans is encoded by the SPTLC1 gene. Dawkins et al. (2001) noted that the SPTLC1 gene maps to chromosome 9q22.1-q22.3. Serine palmitoyltransferase,...

L-Cycloserine is a potent inhibitor of serine palmitoyl transferase (SPT), the first enzyme in the sphingolipid synthesis pathway. It inhibits bacterial SPT activity by 80% at a concentration of 25 µM, which is 100 times more potent than D-cycloserine (Cay-22194). L-Cycloserine inhibits SPT activity up to 86% in a...

Protein function: Serine palmitoyltransferase (SPT) (PubMed:19416851). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core (PubMed:19416851). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (PubMed:19416851). The SPTLC1-SPTLC2-SPTSSA...

Protein function: Serine palmitoyltransferase (SPT) (PubMed:19416851). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core (PubMed:19416851). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (PubMed:19416851). The SPTLC1-SPTLC2-SPTSSA...

Atypical amino acid found in Isaria sinclairi, parent compound of fingolimod, serine palmitoyltransferase inhibitor.