MMP-2 Inhibitor I

MMP-2 Inhibitor I is a hydroxamate-based, long-chain fatty acid that acts as a reversible inhibitor of matrix metalloproteinase (MMP)-2 (Ki = 1.6 µM), a protein implicated in the pathological breakdown of extracellular matrix proteins. Increased levels of MMP-2 are associated with tumor invasion and metastasis. This compound has been shown to attenuate cancer cell migration. It has also been used to preserve blood-brain barrier function in a rat model of pneumococcal meningitis.Formal Name: N-hydroxy-9Z-octadecenamide. CAS Number: 10335-69-0. Synonyms: Matrix Metalloproteinase-2 Inhibitor I, cis-9-Octadecenoyl-N-hydroxylamide, Oleylhydroxamate. Molecular Formula: C18H35NO2. Formula Weight: 297.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/mL, DMSO: 50 mg/mL, Ethanol: 50 mg/mL, Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/mL. SMILES: ONC(CCCCCCC/C=C\CCCCCCCC)=O. InChi Code: InChI=1S/C18H35NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(20)19-21/h9-10,21H,2-8,11-17H2,1H3,(H,19,20)/b10-9-. InChi Key: LTXHELLMCCEDJG-KTKRTIGZSA-N.