MK-571 (sodium salt)

MK-571 (sodium salt)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay70720-1 1 mg -

3 - 10 business days*

Cay70720-5 5 mg -

3 - 10 business days*

Cay70720-10 10 mg -

3 - 10 business days*

Cay70720-50 50 mg -

3 - 10 business days*

The cysteinyl leukotrienes (CysLTs), LTC4, LTD4, and LTE4, mediate their actions through two... more
Product information "MK-571 (sodium salt)"
The cysteinyl leukotrienes (CysLTs), LTC4, LTD4, and LTE4, mediate their actions through two distinct G protein-coupled receptors. LTD4 is the preferred ligand for the cysLT1 receptor, whereas LTC4 and LTD4 bind with approximately equal affinity to the CysLT2 receptor. MK-571 is a selective, orally active CysLT1 receptor antagonist. It blocks the binding of LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively, which is indicative of CysLT1 receptor-mediated activity in these preparations. MK-571 effectively blocks LTD4 activation of recombinant human and mouse CysLT1 receptors but is ineffective at blocking LTC4 or LTD4 activation of the recombinant human or mouse CysLT2 receptors. Formal Name: (E)-3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt. CAS Number: 115103-85-0. Synonyms: L-660,711. Molecular Formula: C26H26ClN2O3S2 . Na. Formula Weight: 537.1. Purity: >95%. Formulation: A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml, H20: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 226, 283, 328, 345, 358 nm. SMILES: CCCSC(SCCC(=O)N(C)C)c1cccc(\C=C/c2ccc3ccc(Cl)cc3n2)c1. InChi Code: InChI=1S/C26H27ClN2O3S2.Na/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22,/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32),/q,+1/p-1/b10-6+,. InChi Key: XNAYQOBPAXEYLI-AAGWESIMSA-M.
Keywords: L-660,711, (E)-3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt
Supplier: Cayman Chemical
Supplier-Nr: 70720


Application: CysLT1 receptor antagonist
MW: 537.1 D
Formula: C26H26ClN2O3S2 . Na
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 115103-85-0| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Our products are for laboratory research use only: Not for administration to humans!
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