MK-0773

MK-0773 is a selective androgen receptor modulator (SARM). It selectively binds to the androgen receptor (AR, IC50 = 6.6 nM) over the glucocorticoid and progesterone receptors (IC50s = >2 µM for both). It is a partial agonist of AR that increases AR-dependent transcription in a reporter assay using MDA-MB-453 cells endogenously expressing AR. MK-0773 (6 mg/kg) increases the bone formation rate with less than a 5% increase in uterine weight in ovariectomized rats and increases seminal vesicle weight to a lesser extent than dihydrotestosterone (DHT) in orchidectomized rats when administered at a dose of 45 mg/kg. It reduces serum total cholesterol levels but also reduces serum HDL levels in ovariectomized rats when administered at a dose of 25 mg/kg.. SMILES: C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])N(C(C(F)=C2)=O)C)([H])[C@@]4([H])[C@](CC3)([C@H](CC4)C(NCC5=NC6=NC=CC=C6N5)=O)C. InChi Code: InChI=1S/C27H34FN5O2/c1-26-11-10-17-15(6-9-21-27(17,2)13-19(28)25(35)33(21)3)16(26)7-8-18(26)24(34)30-14-22-31-20-5-4-12-29-23(20)32-22/h4-5,12-13,15-18,21H,6-11,14H2,1-3H3,(H,30,34)(H,29,31,32)/t15-,16-,17-,18+,21+,26-,27+/m0/s1. InChi Key: GBEUKTWTUSPHEE-JWJWXJQQSA-N