Ketorolac-d5

Ketorolac-d5 is intended for use as an internal standard for the quantification of ketorolac (Cay-9001148) by GC- or LC-MS. Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) and a non-selective COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2). It prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases prostaglandin E2 (PGE2) levels in paw tissue in a mouse model of carrageenan-induced inflammation when administered at a dose of 30 mg/kg. Ketorolac is a racemic mixture containing the active (S)-ketorolac (Cay-11348) and inactive (R)-ketorolac enantiomers. Formulations containing ketorolac have been used to manage postoperative pain and as ophthalmic solutions to treat ocular pain and inflammation.Formal Name: 5-(benzoyl-d5)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. CAS Number: 1215767-66-0. Molecular Formula: C15H8D5NO3. Formula Weight: 260.3. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble, Methanol: slightly soluble. SMILES: O=C(C1=CC=C2N1CCC2C(O)=O)C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H]. InChi Code: InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/i1D,2D,3D,4D,5D. InChi Key: OZWKMVRBQXNZKK-RALIUCGRSA-N.