Jacaric Acid

Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. Structurally, it is an 18-carbon omega-6 triene isomer of gamma-linolenic acid (Cay-90220). Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 µM). It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant alpha-tocopherol, suggesting that apoptosis results from oxidative stress. Jacaric acid is metabolized in vivo to conjugated linoleic acid (Cay-90140), which is also cytotoxic to cancer cells. Jacaric acid inhibits cyclooxygenase-1 in vitro (Ki = 1.7 µM) and, with long term feeding, decreases stearoyl-CoA desaturase expression and activity in mice.Formal Name: 8Z,10E,12Z-octadecatrienoic acid. CAS Number: 28872-28-8. Synonyms: FA 18:3, 8(Z),10(E),12(Z)-Octadecatrienoic Acid. Molecular Formula: C18H30O2. Formula Weight: 278.4. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 100 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 273, 284 nm. SMILES: CCCCC/C=C\C=C\C=C/CCCCCCC(O)=O. InChi Code: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-11H,2-5,12-17H2,1H3,(H,19,20)/b7-6-,9-8+,11-10-. InChi Key: DQGMPXYVZZCNDQ-KDQYYBQISA-N. Side Chain Carbon Sum: 18:3.