HET0016

HET0016
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay75780-1 1 mg -

6 - 10 business days*

15.00€
Cay75780-5 5 mg -

6 - 10 business days*

68.00€
Cay75780-10 10 mg -

6 - 10 business days*

120.00€
Cay75780-100 100 mg -

6 - 10 business days*

900.00€
 
20-HETE is a major biologically active cytochrome P450 (CYP450) metabolite of arachidonic acid in... more
Product information "HET0016"
20-HETE is a major biologically active cytochrome P450 (CYP450) metabolite of arachidonic acid in the kidney and liver. It regulates renal vascular and tubular functions as well as vascular tone in the cerebral circulation. HET0016 is an inhibitor of 20-HETE formation in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms. HET0016 inhibits CYP2C9, CYP2D6, and CYP3A4, enzymes important in drug metabolism, significantly less effectively with IC50s in the µM range. The IC50 values for inhibition of cyclooxygenase and epoxyeicosatrienoic acids (EETs) formation are 2.3 and 2.8 µM, respectively. Formal Name: N-(4-butyl-2-methylphenyl)-N'-hydroxy-methanimidamide. CAS Number: 339068-25-6. Synonyms: N-hydroxy-N'-(4-n-butyl-2-methylphenyl)Formamidine. Molecular Formula: C12H18N2O. Formula Weight: 206.3. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2)(1:1): .5 mg/ml, Ethanol: 14 mg/ml. lambdamax: 210, 257, 291 nm. SMILES: CCCCC1=CC=C(/N=C/NO)C(C)=C1. InChi Code: InChI=1S/C12H18N2O/c1-3-4-5-11-6-7-12(10(2)8-11)13-9-14-15/h6-9,15H,3-5H2,1-2H3,(H,13,14). InChi Key: LYNOGBKNFIHKLE-UHFFFAOYSA-N.
Keywords: N-hydroxy-N'-(4-n-butyl-2-methylphenyl)Formamidine, N-(4-butyl-2-methylphenyl)-N'-hydroxy-methanimidamide
Supplier: Cayman Chemical
Supplier-Nr: 75780

Properties

Application: Bioactive lipid assays
MW: 206.3 D
Formula: C12H18N2O
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 339068-25-6| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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