Flurbiprofen-d3

Flurbiprofen-d3 is intended for use as an internal standard for the quantification of flurbiprofen (Cay-70250, Cay-10004207, Cay-70255) by GC- or LC-MS. Flurbiprofen is a non-selective COX inhibitor (IC50s = 0.04 and 0.51 µM for COX-1 and COX-2, respectively). In vivo, flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats. Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg. Formulations containing flurbiprofen have been used to manage pain and inflammation associated with arthritis.Formal Name: 2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoic-3,3,3-d3 acid. CAS Number: 1185133-81-6. Molecular Formula: C15H10D3FO2. Formula Weight: 247.3. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMF: 25 mg/ml, DMSO: 10 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): 0.9 mg/ml. SMILES: FC1=CC(C(C([2H])([2H])[2H])C(O)=O)=CC=C1C2=CC=CC=C2. InChi Code: InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/i1D3. InChi Key: SYTBZMRGLBWNTM-FIBGUPNXSA-N.