D159687

D159687 is a negative allosteric modulator of phosphodiesterase 4D (PDE4D, IC50 = 28 nM for the human enzyme). It is selective for PDE4D over PDE4B (IC50 = 562 nM for the human enzyme), as well as 14 other PDE isoforms (IC50s = >1.4 µM). D159687 decreases forskolin-induced cAMP hydrolysis in HEK293 cells (IC50 = 253 nM) and dextran gel-induced increases in leukotriene E4 production in isolated human whole blood (IC50 = 44 nM). It impairs novel object recognition in mice when administered at a dose of 3 mg/kg but does not increase anesthesia duration, a proxy measure of emesis induction, in mice at 3 or 10 mg/kg.Formal Name: N-[4-[(3'-chloro-6-methoxy[1,1'-biphenyl]-3-yl)methyl]phenyl]-urea. CAS Number: 1155877-97-6. Molecular Formula: C21H19ClN2O2. Formula Weight: 366.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 10 mg/ml. lambdamax: 246 nm. SMILES: O=C(NC1=CC=C(CC2=CC=C(C(C3=CC(Cl)=CC=C3)=C2)OC)C=C1)N. InChi Code: InChI=1S/C21H19ClN2O2/c1-26-20-10-7-15(12-19(20)16-3-2-4-17(22)13-16)11-14-5-8-18(9-6-14)24-21(23)25/h2-10,12-13H,11H2,1H3,(H3,23,24,25). InChi Key: RJJLUTWHJUDZFP-UHFFFAOYSA-N.