Aranidipine

Aranidipine is an antagonist of voltage-gated calcium channel Cav3.2. It inhibits inward currents in Xenopus oocytes expressing human Cav3.2 channels when used at a concentration of 10 µM. Aranidipine (10 mg/kg) decreases mean blood pressure and increases heart rate in spontaneously hypertensive rats (SHRs). It increases aortic and coronary blood flow and decreases blood pressure, but not heart rate, in normotensive dogs when administered at a dose of 0.3 mg/kg. Aranidipine (10 µg/kg) decreases blood pressure, as well as increases coronary blood flow velocity and heart contractile force, in dogs. It inhibits diet-induced increases in serum levels of total cholesterol, phospholipids, and triglycerides, as well as reduces aortic plaque area, in rabbits fed a high-cholesterol diet when administered at doses of 3 or 10 mg/kg. Formulations containing aranidipine have been used in the treatment of hypertension.Formal Name: 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-yridinedicarboxylic acid, 3-methyl 5-(2-oxopropyl) ester. CAS Number: 86780-90-7. Synonyms: MPC-1304. Molecular Formula: C19H20N2O7. Formula Weight: 388.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: CC(COC(C1=C(C)NC(C)=C(C(OC)=O)C1C2=C([N+]([O-])=O)C=CC=C2)=O)=O. InChi Code: InChI=1S/C19H20N2O7/c1-10(22)9-28-19(24)16-12(3)20-11(2)15(18(23)27-4)17(16)13-7-5-6-8-14(13)21(25)26/h5-8,17,20H,9H2,1-4H3. InChi Key: NCUCGYYHUFIYNU-UHFFFAOYSA-N.