Anecortave Acetate

Anecortave acetate is a sterol lipid. It inhibits VEGF-induced increases in vascular generation, number, and length in isolated rat retinas when used at a concentration of 1 µM. Sub-tenon administration of anecortave acetate (7.5% w/v) prevents and reduces increases in intraocular pressure induced by prednisolone (Cay-20866) in sheep. Subconjunctival administration of anecortave acetate (15% w/v), in combination with 2-deoxyglucose, decreases tumor growth in a Tg(TagRb)1Plm mouse model of retinoblastoma.Formal Name: 21-(acetyloxy)-17-hydroxy-pregna-4,9(11)-diene-3,20-dione. CAS Number: 7753-60-8. Synonyms: AL 3789, NSC 15475, NSC 24345. Molecular Formula: C23H30O5. Formula Weight: 386.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: 10 mg/ml. SMILES: C[C@@]12[C@](CC[C@]2(O)C(COC(C)=O)=O)([H])[C@@]3([H])C([C@@]4(C(CC3)=CC(CC4)=O)C)=CC1. InChi Code: InChI=1S/C23H30O5/c1-14(24)28-13-20(26)23(27)11-8-19-17-5-4-15-12-16(25)6-9-21(15,2)18(17)7-10-22(19,23)3/h7,12,17,19,27H,4-6,8-11,13H2,1-3H3/t17-,19+,21+,22+,23+/m1/s1. InChi Key: YUWPMEXLKGOSBF-GACAOOTBSA-N.