Andrastin A

Andrastin A is a meroterpenoid farnesyltransferase inhibitor. It increases the accumulation and effect of the chemotheraputic agent vincristine (sulfate) (Cay-11764 in multidrug resistant VJ-300 cell culture (the IC50 of vincristine decreased 1.5-20-fold upon treatment with 6.25 µg/ml to 50 µg/ml of of andrastin A), most likely by binding to plasma membrane phosphoglycoprotein to prevent drug efflux. Andrastin A inhibits survival of Caco-2 cells with an IC50 of >50 µg/ml.Formal Name: (3beta,5beta,8alpha,9beta,10alpha,13alpha)-3beta-(acetyloxy)-4,4,8,12,16-pentamethyl-15,17,19-trioxoandrost-11-ene-14-carboxylic acid, methyl ester. CAS Number: 174232-42-9. Synonyms: NSC 697452. Molecular Formula: C28H38O7. Formula Weight: 486.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: CC1=C[C@]2([H])[C@]([C@@](C(C3C)=O)(C(OC)=O)[C@]1(C)C3=O)(C)CC[C@]4([H])C(C)(C)[C@@H](OC(C)=O)CC[C@]42C=O. InChi Code: InChI=1S/C28H38O7/c1-15-13-19-25(6,28(23(33)34-8)22(32)16(2)21(31)26(15,28)7)11-9-18-24(4,5)20(35-17(3)30)10-12-27(18,19)14-29/h13-14,16,18-20H,9-12H2,1-8H3/t16?,18-,19-,20+,25+,26+,27+,28-/m1/s1. InChi Key: GRBXNADBNJGZRK-GJEDHNSHSA-N. Origin: Fungus/Penicillium sp..