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Anti-NASH Agent 1
Item number: Cay42614-10
Anti-NASH agent 1 is an anti-non-alcoholic steatohepatitis (NASH) agent and a derivative of the PPARalpha and PPARdelta agonist GFT505 (elafibranor, Cay-23508). It inhibits free fatty acid-induced triglyceride accumulation and aspartate aminotransferase (AST) activity in HepG2 cells when used at a concentration of...
| Keywords: | Anti-Non-Alcoholic Steatohepatitis Agent 1,... |
| Application: | Anti-NASH (anti-non-alcoholic steatohepatitis) agent |
| CAS | 2409685-41-0 |
| MW: | 423.6 D |
From 109.00€
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Cetirizine N-oxide (hydrochloride)
Item number: Cay42643-1
Cetirizine N-oxide is an oxidative degradation product of the histamine H1 receptor antagonist cetirizine (Cay-19686).. Solulibility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml: DMSO: Slightly Soluble: 0.1-1 mg/ml, Water: Slightly Soluble: 0.1-1 mg/ml.
| Keywords: | 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-oxido-1-piperazinyl]ethoxy]-acetic acid, dihydrochloride |
| Application: | Oxidative histamine H1 receptor antagonist cetirizine degradation product |
| MW: | 477.81 D |
From 121.00€
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Corosolic Acid beta
Item number: Cay42738-1
Corosolic acid beta is a synthetic pentacyclic triterpenoid and derivative of corosolic acid (Cay-27887) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and siRNA in vitro and in vivo. It also inhibits glycogen phosphorylase (IC50 = 82. µM for the rabbit muscle enzyme)....
| Keywords: | CAbeta, 2a,3beta-dihydroxy-urs-12-en-28-oic acid, propyl ester |
| Application: | Synthetic pentacyclic triterpenoid, LNP formation |
| CAS | 958237-73-5 |
| MW: | 514.79 D |
From 136.00€
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DMG-PEG(2000) (solution)
Item number: Cay42746-1
DMG-PEG(2000) is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles. Administration of fumarylacetoacetate hydrolase (FAH) mRNA in DMG-PEG(2000)-containing lipid nanoparticles increases survival in a mouse model of hereditary tyrosinemia type 1 (HT-1)....
| Keywords: | 1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000,... |
| Application: | Lipid excipient, lipid nanoparticle formation |
| CAS | 160743-62-4 |
From 35.00€
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Lyso-Monosialoganglioside GM3 (synthetic)
Item number: Cay42762-500
Lyso-monosialoganglioside GM3 (Lyso-GM3) is a form of ganglioside GM3 (Cay-31711, Cay-15587) that is lacking the fatty acyl group. It inhibits EGF-induced increases in EGFR kinase activity in A431 epithelial cancer cells when used at a concentration of 500 µM. This product is fully synthetic and has no variations in...
| Keywords: | Lysoganglioside GM3, Lyso-GM3, lyso-Monosialoganglioside GM3, 2S-amino-3R-hydroxy-4E-octadecen-1-yl... |
| Application: | Ganglioside |
| CAS | 94458-63-6 |
| MW: | 915.04 D |
994.00€
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FO-32
Item number: Cay42922-1
FO-32 is an ionizable cationic lipid (pKa = 6.36) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. Intranasal administration of LNPs containing FO-32 and encapsulating reporter mRNA accumulate in nasal epithelial tissue and lungs in mice. Nebulized administration...
| Keywords: | di(dec-3-yn-1-yl) 5-(butylcarbamoyl)-5-(N-(3-(dimethylamino)propyl)-6-(heptadecan-9-yloxy)-6-oxohexanamido)nonanedioate |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 1026.58 D |
From 102.00€
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C24:1 Ganglioside GM2 (d18:1/24:1) (ammonium salt)
Item number: Cay42983-100
C24:1 Ganglioside GM2 is an endogenous monosialylated ganglioside. It is a self-lipid that binds to CD1d in HEK293T cells. C24:1 Ganglioside GM2 has been found as a minor ganglioside GM2 species in human brain from a patient with variant B Tay-Sachs disease. As this product is derived from a natural source, there...
| Keywords: | C24:1 GM2, N-Nervonoyl-(cis-15)-monosialoganglioside GM2, N-Selacholeoyl-(cis-15)-monosialoganglioside GM2,... |
| Application: | Sphingolipid, endogenous monosialylated ganglioside |
| MW: | 1483.88 D |
355.00€
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Lyso-Disialoganglioside GD3 (ammonium salt, synthetic)
Item number: Cay42821-500
Lyso-disialoganglioside GD3 (Lyso-GD3) is a form of ganglioside GD3 (Cay-31709, Cay-17481) lacking the fatty acyl group. This product is fully synthetic and has no variations in the sphingoid backbone.. Solulibility: Ethanol: Sparingly soluble: 1-10 mg/ml: .
| Keywords: | lyso-Disialoganglioside GD3, Lysoganglioside GD3, Lyso-GD3, 2S-amino-3R-hydroxy-4E-octadecen-1-yl... |
| Application: | Ganglioside |
| MW: | 1206.29 D |
685.00€
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LipidLaunch(TM) Helper Lipid Set
Item number: Cay42831-1
The LipidLaunchTM Helper Lipid Set includes cholesterol, 1,2-dimyristoyl-rac-3-PEG(2000) (DMG-PEG(2000), Cay-33945), and 1,2-distearoyl-sn-glycero-3-PC (1,2-DSPC, Cay-39189) for use in lipid nanoparticle (LNP) formulations. Cholesterol and 1,2-DSPC are formulated at 25 mM and DMG-PEG(2000) at 10 mg/ml in ethanol for...
| Application: | LNP formulation helper lipid set |
233.00€
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9C-SCC-10
Item number: Cay42886-1
9C-SCC-10 is a crown-like biodegradable ionizable cationic lipid (pKa = 6.42) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. LNPs containing 9C-SCC-10 selectively accumulate in mouse liver.. Solulibility: Methyl Acetate: Soluble: =10 mg/ml: .
| Keywords: | ((((3,3',3''-(1,4,7-triazonane-1,4,7-triyl)tris(propanoyl))tris(oxy))tris(ethane-2,1-diyl))tris(disulfanediyl))tris(ethane... |
| Application: | Crown-like ionizable cationic lipid, LNP formation |
| MW: | 1481.34 D |
From 81.00€
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FO-35
Item number: Cay42923-1
FO-35 is an ionizable cationic lipid (pKa = 7.67) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. Intranasal administration of LNPs containing FO-35 and encapsulating reporter mRNA accumulate in nasal epithelial tissue in mice. Nebulized administration of...
| Keywords: | bis((4-(prop-1-en-2-yl)cyclohex-1-en-1-yl)methyl)... |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 1064.63 D |
From 150.00€
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BCP-NC2-C12
Item number: Cay42940-10
BCP-NC2-C12 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. LNPs containing BCP-NC2-C12 accumulate primarily in the liver and spleen of mice. LNPs containing BCP-NC2-C12 and encapsulating mRNA encoding the Cas9 nuclease and...
| Keywords: | N1,N3-bis(2-(didodecylamino)ethyl)bicyclo[1.1.1]pentane-1,3-dicarboxamide |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 913.6 D |
From 48.00€
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