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LY255283
Item number: Cay70715-10
Antagonists of the chemotactic and inflammatory lipoxygenase product leukotriene B4 (LTB4) have been potential drug development targets for several years. The tetrazole LY255283 is a competitive antagonist of the BLT2 receptor. It displaces radiolabeled LTB4 from guinea pig lung membrane, with an IC50 of about 100...
| Keywords: | 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]-ethanone |
| Application: | BTL2 receptor antagonist |
| CAS | 117690-79-6 |
| MW: | 360.5 D |
From 40.00€
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alpha-Linolenic Acid-d5
Item number: Cay9002286-100
alpha-Linolenic acid-d5 (ALA-d5) is intended for use as an internal standard for the quantification of ALA (Cay-90210) by GC- or LC-MS. ALA is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum...
| Keywords: | ALA-d5, 9Z,12Z,15Z-octadecatrienoic-17,17',18,18,18-d5 acid |
| Application: | ALA quantification, internal standard, GC, LC-MS |
| CAS | 145191-04-4 |
| MW: | 283.5 D |
From 103.00€
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Cholic Acid 7-sulfate
Item number: Cay9002532-1
Cholic acid 7-sulfate is a metabolite of the primary bile acid cholic acid (Cay-20250). It is produced by conjugation of a sulfate group with the hydroxy group at position 7 of cholic acid in the liver and gut. Fecal levels of cholic acid 7-sulfate are increased in male, but not female, mice fed a diet supplemented...
| Keywords: | 7-Sulfocholate, 7-Sulfocholic Acid, (3alpha,5beta,7alpha,12alpha)-3,12-dihydroxy-7-(sulfooxy)-cholan-24-oic acid |
| Application: | Bile acid metabolite |
| CAS | 60320-05-0 |
| MW: | 488.6 D |
From 89.00€
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PtdIns-(3,5)-P2 (1,2-dioctanoyl) (sodium salt)
Item number: Cay10007763-100
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,5)-P2 (1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C8:0 fatty...
| Keywords: | DOPI-3,5-P2, Phosphatidylinositol-3,5-bisphosphate C-8, 1-(1,2-dioctanoylphosphatidyl)inositol-3,5-bisphosphate, trisodium... |
| Application: | Bioactive lipid assays |
| MW: | 812.5 D |
From 78.00€
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10-Nitrooleate
Item number: Cay10008043-1
Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate (LNO2, Cay-10037), cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as potent endogenous ligands for PPARgamma and can also decompose or be metabolized...
| Keywords: | 10-nitro-9-trans-Octadecenoic Acid, 10-Nitrooleic Acid, 10-nitro-9E-octadecenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 875685-46-4 |
| MW: | 327.5 D |
From 126.00€
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LY293111
Item number: Cay10009768-500
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from the 5-lipoxygenase pathway of arachidonic acid metabolism and is an important mediator of the inflammatory process. LY293111 is a potent antagonist of the leukotriene B4 (LTB4) receptor, BLT1, that inhibits the specific binding of radiolabeled-LTB4 to...
| Keywords: | Etalocib, VML 295, 2-[3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]4-yl)oxy]propoxy]-2-propylphenoxy]-benzoic acid |
| Application: | BLT1 antagonist |
| CAS | 161172-51-6 |
| MW: | 544.6 D |
From 101.00€
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Resolvin E1-d4
Item number: Cay10009854-10
Resolvin E1-d4 (RvE1-d4) is intended for use as an internal standard for the quantification of RvE1 (Cay-10007848) by GC- or LC-MS. RvE1 is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids. It is produced from eicosapentaenoic acid (EPA, Cay-90110, Cay-90110.1, Cay-21908) via an...
| Keywords: | RvE1-d4, 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic-6,7,14,15-d4 acid |
| Application: | GC-MS, LC-MS, internal standard |
| MW: | 354.5 D |
From 312.00€
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DDMS
Item number: Cay10018-1
Biosynthesis of 20-HETE from arachidonic acid by the cytochrome P450 4A (CYP450 4A) isoforms is an important component of vascular homeostasis, especially in renal circulation. DDMS is a mechanism-based, irreversible inhibitor that has about 10-fold selectivity for the CYP4A2 enzyme which predominantly synthesizes...
| Keywords: | Dibromo-dodecenyl-methylsulfimide, 12,12-dibromo-N-(methylsulfonyl)-11-dodecenamide |
| Application: | CYP450 4A2 inhibitor |
| CAS | 206052-03-1 |
| MW: | 433.2 D |
From 108.00€
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(±)7(8)-DiHDPA
Item number: Cay10469-50
(±)7(8)-DiHDPA is a major metabolite of docosahexaenoic acid (DHA, Cay-90310) that is produced via oxidation by cytochrome P450 epoxygenases. Epoxygenase metabolites of DHA, including (±)7(8)-DiHDPA, suppress aggregation and thromboxane synthesis in isolated platelets.Formal Name:...
| Keywords: | (±)7,8-dihydroxydocosa-4Z,10Z,13Z,16Z,19Z-pentaenoic acid |
| CAS | 168111-93-1 |
| MW: | 362.5 D |
From 132.00€
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8-iso Prostaglandin E2
Item number: Cay14350-500
8-iso Prostaglandin E2 (8-iso PGE2) is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively. When infused into the renal...
| Keywords: | 8-epi PGE2, 8-iso PGE2, 9-oxo-11alpha,15S-dihydroxy-(8beta)-prosta-5Z,13E-dien-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 27415-25-4 |
| MW: | 352.5 D |
From 87.00€
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Lipid-based Drug Delivery Tools
1-Stearoyl-2-hydroxy-sn-glycero-3-PC
Item number: Cay15107-100
1-Stearoyl-2-hydroxy-sn-glycero-3-PC is a saturated lysophosphatidylcholine. It increases IL-1beta production in isolated human blood monocytes when used at a concentration of 12.5 µM. Plasma levels of 1-stearoyl-2-hydroxy-sn-glycero-3-PC are decreased in patients with lung cancer.Formal Name:...
| Keywords: | 1-Octadecanoyl-2-hydroxy-sn-glycero-3-phosphatidylcholine, 1-Stearoyl-2-hydroxy-sn-glycero-3-Phosphocholine,... |
| Application: | Lysophosphatidylcholine |
| CAS | 19420-57-6 |
| MW: | 523.7 D |
From 97.00€
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Latanoprost (free acid)
Item number: Cay16811-1
Latanoprost (free acid) is a derivative of prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020), an FP receptor agonist, and an active metabolite of the prodrug latanoprost (Cay-16812). It selectively binds to the FP receptor (Ki = 0.098 µM) over the EP1, EP2, EP3, and EP4 receptors (Kis = 2.06, 39.667, 7.519,...
| Keywords: | 17-phenyl-13,14-dihydro trinor Prostaglandin F2alpha, Lat-FA, PhXA-85,... |
| Application: | FP receptor agonist |
| CAS | 41639-83-2 |
| MW: | 390.5 D |
From 116.00€
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