PtdIns-(3,5)-P2 (1,2-dioctanoyl) (sodium salt)

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,5)-P2 (1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. PtdIns are phosphorylated to mono- (PtdIns-P, PIP), di- (PtdIns-P2, PIP2), and triphosphates (PtdIns-P3, PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade. PtdIns-(3,4)-P2 is resistant to hydrolysis by phospholipase C.Formal Name: 1-(1,2-dioctanoylphosphatidyl)inositol-3,5-bisphosphate, trisodium salt. Synonyms: DOPI-3,5-P2, Phosphatidylinositol-3,5-bisphosphate C-8, PI(3,5)P2 (8:0/8:0), PIP2[3',5'](8:0/8:0). Molecular Formula: C25H46O19P3 . 3Na. Formula Weight: 812.5. Purity: >98%. Formulation: (Request formulation change), A lyophilized powder. SMILES: O=C(OC[C@H](COP(O[C@@H]1[C@H](O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H](OP([O])(O)=O)[C@H]1O)([O-])=O)OC(CCCCCCC)=O)CCCCCCC.[Na+].[Na].[Na+]. InChi Code: InChI=1S/C25H49O19P3.3Na/c1-3-5-7-9-11-13-18(26)39-15-17(41-19(27)14-12-10-8-6-4-2)16-40-47(37,38)44-25-21(29)23(42-45(31,32)33)20(28)24(22(25)30)43-46(34,35)36,,,/h17,20-25,28-30H,3-16H2,1-2H3,(H,37,38)(H2,31,32,33)(H2,34,35,36),,,/q,3*+1/p-3/t17-,2. InChi Key: YFJGBHCKHDYSQL-BHSPMXJGSA-K. Side Chain Carbon Sum: 16:0.