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Irigenin
Item number: Cay34676-10
Irigenin is a polyketide synthase-derived isoflavonoid that has been found in B. chinensis rhizomes and has diverse biological activities. It inhibits the cytochrome P450 (CYP) isoform CYP1A (IC50 = 1.2 µM) and induces a 2-fold increase in NADPH quinone reductase activity in Hepa-1c1c7 cells when used at a...
| Keywords: | 5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one |
| Application: | Bioactive isoflavonoid |
| CAS | 548-76-5 |
| MW: | 360.3 D |
From 68.00€
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CAY10790
Item number: Cay35326-1
CAY10790 is a cysteinyl leukotriene 1 (CysLT1) receptor antagonist (IC50 = 2.8 µM) and G protein-coupled bile acid receptor 1 (GPBAR1) agonist. It induces receptor transactivation in HEK293T cells expressing human GPBAR1 (EC50 = 3 µM). CAY10790 (10 µM) reduces TNF-alpha and IL-1beta levels in LPS-stimulated RAW...
| Keywords: | 3-(2-quinolinylmethoxy)-benzoic acid |
| Application: | CysLT1 receptor antagonist, GPBAR1 agonist |
| CAS | 107813-86-5 |
| MW: | 279.3 D |
From 67.00€
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Chenodeoxycholic Acid (sodium salt)
Item number: Cay35346-1
Chenodeoxycholic acid (CDCA) is a hydrophobic primary bile acid. It is formed from cholesterol in the liver via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. CDCA is a farnesoid X receptor (FXR) agonist that binds to FXRs in a TR-FRET assay (EC50 = 13 µM) and...
| Keywords: | CDCA, NSC 681066, (5beta)-3alpha,7alpha-dihydroxy-cholan-24-oic acid, monosodium salt |
| Application: | Primary bile acid, FXR agonist |
| CAS | 2646-38-0 |
| MW: | 414.6 D |
From 54.00€
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beta-Hyodeoxycholic Acid (hydrate)
Item number: Cay35378-1
beta-Hyodeoxycholic acid is a 3beta epimer of the secondary bile acid hyodeoxycholic acid (HDCA, Cay-20294). Levels of beta-hyodeoxycholic acid are increased in the feces of hamsters fed a diet containing HDCA- or hyocholic acid (HCA, Cay-20293).Formal Name: (5beta)-3beta,6alpha-dihydroxy-cholan-24-oic acid,...
| Keywords: | 3beta,6alpha-dihydroxy-5beta-Cholan-24-oic Acid, isoHDCA, Isohyodeoxycholic Acid,... |
| Application: | Hyodeoxycholic acid 3beta epimer |
| MW: | 392.6 D |
From 85.00€
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Tirucallol
Item number: Cay35623-1
Tirucallol is a triterpenoid that has been found in Camellia and has reverse transcriptase inhibitory and anti-inflammatory activities. It inhibits HIV-1 reverse transcriptase (IC50 = 3.8 µM). Tirucallol (25, 50, and 100 µM) reduces nitric oxide (NO) and prostaglandin E2 (PGE2, Cay-14010) production in...
| Keywords: | (+)-Tirucallol, NSC 403164, (3beta,13alpha,14beta,17alpha,20S)-lanosta-8,24-dien-3-ol |
| Application: | Triterpenoid, reverse transcriptase inhibitory / anti-inflammatory agent |
| CAS | 514-46-5 |
| MW: | 426.7 D |
From 211.00€
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YSK05
Item number: Cay35786-10
YSK05 is an ionizable cationic amino lipid (apparent pKa = ~6.5) that has been used in combination with other lipids in the formation of liposomes and lipid nanoparticles (LNPs). Administration of cyclic di-GMP (Cay-17144) in YSK05-containing liposomes increases serum levels of IFN-beta, IFN-gamma, IL-6, and...
| Keywords: | 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]-piperidine |
| Application: | Ionizable amino lipid, LNP formation |
| CAS | 1318793-78-0 |
| MW: | 628.1 D |
From 118.00€
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N-acetyl-2-Aminophenol
Item number: Cay35829-100
N-acetyl-2-Aminophenol is a derivative of the analgesic and antipyretic acetaminophen (Cay-10024) that has been found in P. fluorescens. It inhibits platelet aggregation induced by ADP (Cay-16778, Cay-21121) or arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) in isolated human platelet-rich plasma when used...
| Keywords: | 2-Acetamidophenol, 2-Acetaminophenol, AAP, N-acetyl-o-Aminophenol, N-acetyl-ortho-Aminophenol, NSC 3989, Orthocetamol,... |
| Application: | Acetaminophen derivative |
| CAS | 614-80-2 |
| MW: | 151.2 D |
From 40.00€
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Metapristone
Item number: Cay36380-1
Metapristone is an active metabolite of the glucocorticoid, progesterone, and androgen receptor antagonist mifepristone (Cay-10006317). It is formed from mifepristone by the cytochrome P450 (CYP) isoform CYP3A4. Metapristone is an antagonist of human glucocorticoid and progesterone receptors with relative affinities...
| Keywords: | N-desmethyl Mifepristone, N-desmethyl RU-486, RU-42633,... |
| Application: | Abortifacient mifepristone active metabolite |
| CAS | 104004-96-8 |
| MW: | 415.6 D |
From 115.00€
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1,2-Dioleoyl-sn-glycero-3-EPC (chloride)
Item number: Cay36473-10
1,2-Dioleoyl-sn-glycero-3-EPC is a cationic esterized phospholipid. It has been used in combination with other lipids in the formation of lipid bilayers.Formal Name: 4-ethoxy-N,N,N-trimethyl-10-oxo-7R-[[(9Z)-1-oxo-9-octadecenyl] oxy]-3,5,9-trioxa-4-phosphaheptacos-18Z-en-1-aminium 4-oxide, monochloride. CAS Number:...
| Keywords: | 1,2-Dioleoyl-sn-glycero-3-Ethylphosphocholine, 18:1-EPC, 4-ethoxy-N,N,N-trimethyl-10-oxo-7R-[[(9Z)-1-oxo-9-octadecenyl]... |
| Application: | Cationic esterized phospholipid, lipid bilayer formation |
| CAS | 474945-24-9 |
| MW: | 850.6 D |
From 77.00€
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DLin-DMA
Item number: Cay36701-10
DLin-DMA is an ionizable cationic amino lipid (pKa = 6.7) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of nucleic acids.Formal Name: N,N-dimethyl-2,3-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]-1-propanamine. CAS Number: 871258-12-7. Synonyms:...
| Keywords: | 1,2-Dilinoleyloxy-N,N-dimethyl-3-aminopropane, N,N-dimethyl-2,3-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]-1-propanamine |
| Application: | Ionizable amino lipid |
| CAS | 871258-12-7 |
| MW: | 616.1 D |
From 68.00€
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1-Oleoyl-2-Lauroyl-3-Palmitoyl-rac-glycerol
Item number: Cay36859-1
1-Oleoyl-2-lauroyl-3-palmitoyl-rac-glycerol is a triacylglycerol that contains oleic acid (Cay-90260, Cay-24659), lauric acid (Cay-10006626), and palmitic acid (Cay-10006627) at the sn-1, sn-2, and sn-3 positions, respectively. It has been found in a variety of plant oils, including walnut, almond, poppy seed, and...
| Keywords: | 1-Olein-2-Laurin-3-Palmitin, TG(18:1/12:0/16:0), (9Z)-octadecenoic acid,... |
| Application: | Triacylglycerol |
| CAS | 1183882-29-2 |
| MW: | 777.3 D |
From 97.00€
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10-oxo-12(Z),15(Z)-Octadecadienoic Acid
Item number: Cay36976-100
10-oxo-12(Z),15(Z)-Octadecadienoic acid is an oxylipin. It is produced from alpha-linolenic acid (Cay-90210, Cay-21910) by the gut bacteria L. plantarum. Octadecadienoic acid reduces the increase in mRNA expression levels of the gene encoding SREBP-1c induced by the liver X receptor agonist T0901317 (Cay-71810) in...
| Keywords: | 10-oxo-12(Z),15(Z)-18:2, 10-oxo-12(Z),15(Z)-ODE, 10-oxo-12Z,15Z-octadecadienoic acid |
| Application: | Oxylipin gut microbiota metabolite |
| CAS | 1036406-73-1 |
| MW: | 294.4 D |
From 139.00€
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