Tirucallol

Tirucallol is a triterpenoid that has been found in Camellia and has reverse transcriptase inhibitory and anti-inflammatory activities. It inhibits HIV-1 reverse transcriptase (IC50 = 3.8 µM). Tirucallol (25, 50, and 100 µM) reduces nitric oxide (NO) and prostaglandin E2 (PGE2, Cay-14010) production in LPS-stimulated isolated mouse peritoneal macrophages. Topical application of tirucallol (0.25, 0.5, and 1 mg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014) in mice.Formal Name: (3beta,13alpha,14beta,17alpha,20S)-lanosta-8,24-dien-3-ol. CAS Number: 514-46-5. Synonyms: NSC 403164, (+)-Tirucallol. Molecular Formula: C30H50O. Formula Weight: 426.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetone: soluble, DMSO: 10mM. SMILES: C[C@@]12C3=C(CC[C@]1([C@](CC2)([H])[C@@H](C)CC/C=C(C)\C)C)[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC3)C. InChi Code: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25-,26-,28+,29-,30+/m0/s1. InChi Key: CAHGCLMLTWQZNJ-HGKXYCPESA-N. Origin: Plant/Euphorbia ebracteolata Hayata.