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Liriodendrin
Item number: Cay40743-1
Liriodendrin is a lignan glucoside that has been found in B. diffusa and has diverse biological activities. It prevents LPS-induced increases in nitrite (NO), prostaglandin E2 (PGE2, Cay-14010), TNF-alpha, inducible nitric oxide synthase (iNOS), and COX-2 levels in RAW 264.7 macrophages when used at a concentration...
| Keywords: | (+)-Syringaresinol di-O-beta-D-glucoside, (+)-Syringaresinol-4,4'-di-O-beta-D-glucopyranoside, Acanthoside D,... |
| Application: | Bioactive lignan glucoside |
| CAS | 573-44-4 |
| MW: | 742.7 D |
473.00€
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2008-11-10 00:00:00
Item number: Cay40747-10
11-10-8 is an ionizable cationic lipid (pKa = 6.22) that has been used in the generation of lipid nanoparticles (LNPs) for mRNA delivery in vivo. LNPs containing 11-10-8 and encapsulating mRNA encoding the Cas9 nuclease and small-guide RNA (sgRNA) targeting transthyretin (TTR), a thyroid hormone carrier protein,...
| Keywords: | ((2-(pyrrolidin-1-yl)ethyl)azanediyl)bis(decane-1,2-diyl) dioctanoate |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 679.1 D |
From 157.00€
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GW 870086
Item number: Cay40786-10
GW 870086 is a cyano- and isopropyl-substituted derivative of the synthetic corticosteroid and glucocorticoid receptor agonist fluticasone propionate (Cay-20703). It selectively inhibits TNF-alpha-induced transcriptional activity of NF-kappaB in a reporter assay using A549 cells (IC50 = 0.08 nM) over a panel of 50...
| Keywords: | 6alpha,9-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-[[(2,2,3,3-tetramethylcyclopropyl)carbonyl]oxy]-androsta-1,4... |
| Application: | Fluticasone propionate derivative |
| CAS | 827319-43-7 |
| MW: | 559.6 D |
From 133.00€
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Lipid 2-10
Item number: Cay40811-1
Lipid 2-10 is an ionizable cationic lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs).Formal Name: 10-[[3-(dimethylamino)propyl](1-oxooctyl)amino]-nonadecanedioic acid, 1,19-bis(1-hexylheptyl) ester. CAS Number: 2055939-68-7. Molecular Formula: C58H114N2O5....
| Keywords: | 10-[[3-(dimethylamino)propyl](1-oxooctyl)amino]-nonadecanedioic acid, 1,19-bis(1-hexylheptyl) ester |
| Application: | Ionizable cationic lipid, LNP formation |
| CAS | 2055939-68-7 |
| MW: | 919.5 D |
From 73.00€
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Ziyuglycoside II
Item number: Cay40831-10
Ziyuglycoside II is a steroid glycoside that has been found in S. officinalis and has diverse biological activities. It is cytotoxic to SMMC-7721, PC-9, HCT116, MCF-7, and MDA-MB-231 cancer cells when used at concentrations of 30 and 90 µg/ml. Ziyuglycoside II (6, 12, and 18 mg/kg) increases the number of white...
| Keywords: | ZGS II, 3beta-(alpha-L-arabinopyranosyloxy)-19-hydroxy-urs-12-en-28-oic acid |
| Application: | Bioactive glycoside |
| CAS | 35286-59-0 |
| MW: | 604.8 D |
From 73.00€
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C10-200
Item number: Cay40863-10
C10-200 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. LNPs containing C10-200 and encapsulating mRNA encoding a luciferase reporter selectively induce luminescence in the livers of mice to a greater extent than LNPs containing the...
| Keywords: | 1,1'-((2-(4-(2-((2-(bis(2-hydroxydecyl)amino)ethyl)(2-hydroxydecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(decan-2-ol) |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 996.7 D |
From 110.00€
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Lipid U-101
Item number: Cay40902-10
Lipid U-101 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing lipid U-101 and encapsulating mRNA encoding a fusion protein composed of IL-2, a linker, and CD25 inhibit tumor growth in an MC-38 mouse...
| Keywords: | bis(2-hexyldecyl) 6,6'-((3-(bis(2-hydroxyethyl)amino)propyl)azanediyl)dihexanoate |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 839.4 D |
From 228.00€
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Cholesteryl Butyrate
Item number: Cay40950-10
Cholesteryl butyrate is a cholesterol ester that has been used with other lipids in the generation of lipid nanoparticles (LNPs). LNPs containing cholesteryl butyrate decrease proliferation, induce cell death, as well as decrease c-Myc levels in cancer cells.Formal Name: cholest-5-en-3beta-ol, 3-butanoate. CAS...
| Keywords: | Chol-Butyrate, Cholesterol n-butyrate, cholest-5-en-3beta-ol, 3-butanoate |
| Application: | Cholesterol ester, LNP formation |
| CAS | 521-13-1 |
| MW: | 456.8 D |
From 88.00€
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Lipid HTO12
Item number: Cay41202-10
Lipid HTO12 is an ionizable cationic lipid (pKa = 6.432) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing lipid HTO12 and encapsulating adenine base editor mRNA targeting Pcsk9 reduce hepatic Pcsk9 levels...
| Keywords: | heptadecan-9-yl 8-((2-hydroxyethyl)(2-hydroxytetradecyl)amino)octanoate |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 654.1 D |
From 147.00€
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Ganglioside GM1 (bovine) (sodium salt)
Item number: Cay41206-1
Ganglioside GM1 is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue. It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane. It associates with growth factor receptors, including TrkA,...
| Keywords: | GM1, Ganglioside G4, Monosialoganglioside GM1 |
| Application: | Monosialylated ganglioside |
| CAS | 37758-47-7 |
| MW: | 1568.8 D |
From 88.00€
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1,2-Dipalmitoyl-sn-glycero-3-EPC (chloride)
Item number: Cay15099-5
1,2-Dipalmitoyl-sn-glycero-3-EPC is a phospholipid containing the saturated long-chain (16:0) stearic acid inserted at the sn-1 and sn-2 positions and an alkyl group on the phosphate oxygen of the polar headgroup. Cationic phospholipids such as this have proved useful as DNA transfection agents and for studies of...
| Keywords: | 1,2-Dipalmitoyl-sn-glycero-3-Ethylphosphocholine, 16:1-EPC, DPEPC, EDPPC,... |
| Application: | Cationic phospholipid |
| CAS | 328250-18-6 |
| MW: | 798.6 D |
73.00€
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Delphinidin-3-O-rutinoside (chloride)
Item number: Cay33552-1
Delphinidin-3-O-rutinoside is a glycosylated anthocyanin that has been found in R. nigrum and has antioxidant activity. It inhibits loss of viability in isolated rat aortic smooth muscle cells (SMCs), but not MH1C1 hepatoma cells, induced by tert-butyl-hydroperoxide (TBHP) when used at a concentration of 100 µM....
| Keywords: | Delphinidin 3-rutinoside, Tulipanin,... |
| Application: | Glycosylated anthocyanin, antioxidant agent |
| CAS | 15674-58-5 |
| MW: | 647 D |
From 216.00€
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