Ziyuglycoside II

Ziyuglycoside II is a steroid glycoside that has been found in S. officinalis and has diverse biological activities. It is cytotoxic to SMMC-7721, PC-9, HCT116, MCF-7, and MDA-MB-231 cancer cells when used at concentrations of 30 and 90 µg/ml. Ziyuglycoside II (6, 12, and 18 mg/kg) increases the number of white blood cells in peripheral blood and the number of hematopoietic stem and progenitor cells (HSPCs) in a mouse model of leukopenia induced by the nitrogen mustard alkylating agent cyclophosphamide (Cay-13849). It also reduces small intestinal epithelial cell apoptosis and IL-1beta, IL-6, and TNF-alpha levels, as well as improves diarrhea symptoms in a mouse model of rotavirus-induced diarrhea.Formal Name: 3beta-(alpha-L-arabinopyranosyloxy)-19-hydroxy-urs-12-en-28-oic acid. CAS Number: 35286-59-0. Synonyms: ZGS II. Molecular Formula: C35H56O8. Formula Weight: 604.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble: 0.1-1 mg/ml, Ethanol: Slightly soluble: 0.1-1 mg/ml. SMILES: OC([C@]12[C@]([C@](O)([C@@H](CC2)C)C)([H])C3=CC[C@@]([C@@]4([C@@](C(C)([C@H](CC4)O[C@H]5[C@@H]([C@H]([C@H](CO5)O)O)O)C)([H])CC6)C)([H])[C@]6(C)[C@@]3(CC1)C)=O. InChi Code: InChI=1S/C35H56O8/c1-19-10-15-35(29(39)40)17-16-32(5)20(27(35)34(19,7)41)8-9-23-31(4)13-12-24(30(2,3)22(31)11-14-33(23,32)6)43-28-26(38)25(37)21(36)18-42-28/h8,19,21-28,36-38,41H,9-18H2,1-7H3,(H,39,40)/t19-,21+,22+,23-,24+,25+,26-,27-,28+,31+,32-,33-,34-,35+/m1/s1. InChi Key: MFIXLWYJTVEVGO-YHGWSDCJSA-N. Origin: Plant/Sanguisorba officinalis L..