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14S(15R)-EET
Item number: Cay9004352-100
14S(15R)-EET is an oxylipin and a metabolite of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607). It is formed via oxidation of arachidonic acid by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. 14S(15R)-EET (1 µM) induces relaxation in precontracted isolated bovine coronary arteries.Formal Name:...
| Keywords: | 14S(15R)-EpETrE, 14S(15R)-epoxy-5(Z),8(Z),11(Z)-ETrE, 14S(15R)-epoxy-all-cis-5,8,11-Eicosatrienoic Acid,... |
| Application: | Oxylipin, arachidonic acid metabolite |
| CAS | 105304-92-5 |
| MW: | 320.5 D |
From 426.00€
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1,2-Hexadecanediol
Item number: Cay17445-10
1,2-Hexadecanediol is a hydroxyl-substituted hexadecane. It has been used with iron (III) acetylacetonate in the synthesis of monodisperse iron-, cobalt-, or manganese-containing lipid nanoparticles (LNPs) or cobalt-iron nanocrystals. Formulations containing 1,2-hexadecanediol have been used as hair and skin...
| Keywords: | Cetyl glycol, NSC 71525, hexadecane-1,2-diol |
| Application: | Hydroxyl-substituted hexadecane |
| CAS | 6920-24-7 |
| MW: | 258.4 D |
From 97.00€
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MPLA
Item number: Cay25998-100
MPLA is a synthetic derivative of lipid A, a component of bacterial LPS, that is hexa-acylated in contrast to lipid A monophosphoryl from S. minnesota R595 (Cay-25848), which can be hepta-, hexa-, or penta-acylated. MPLA is an agonist of toll-like receptor 4 (TLR4). Intramuscular injection of MPLA (5 µg/100 µl) in...
| Keywords: | Glucopyranosyl Lipid A, Monophosphoryl Lipid A, 3-[(3R)-3-hydroxytetradecanoate],... |
| Application: | Synthetic lipid A derivative, TLR4 agonist |
| CAS | 1246298-63-4 |
| MW: | 1763.5 D |
438.00€
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BODIPY-Linoleate
Item number: Cay29795-1
BODIPY-Linoleate is a fluorescently tagged derivative of linoleic acid (Cay-90150, Cay-90150.1, Cay-21909). BODIPY displays excitation/emission maxima of 470/503 nm, respectively.Formal Name: (9Z,12Z)-17-(5,5-difluoro-5H-5l4,6l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)heptadeca-9,12-dienoic acid. Molecular...
| Keywords: | (9Z,12Z)-17-(5,5-difluoro-5H-5l4,6l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)heptadeca-9,12-dienoic acid |
| Application: | Fluorescently tagged linoleic acid derivative |
| MW: | 456.4 D |
From 519.00€
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Clerosterol
Item number: Cay35862-1
Clerosterol is a phytosterol that has been found in C. fragile and has diverse biological activities. It is active against T. b. brucei (IC50 = 53.6 µg/ml). Clerosterol inhibits the proliferation of A2058 melanoma cells (IC50 = 150 µM). It induces apoptosis, cell cycle arrest at the sub-G1 phase, and mitochondrial...
| Keywords: | (-)-Clerosterol, NSC 144945, Delta5,25-Stigmastadienol, (3beta,24S)-stigmasta-5,25-dien-3-ol |
| Application: | Bioactive phytosterol |
| CAS | 2364-23-0 |
| MW: | 412.7 D |
498.00€
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11alpha-Hydroxyprogesterone
Item number: Cay35898-1
11alpha-Hydroxyprogesterone (11alpha-OHP) is an inhibitor of 11beta-hydroxysteroid dehydrogenase (IC50s = 0.63 and 0.4 µM for recombinant human 11beta-HSD1 and 11beta-HSD2, respectively) and a derivative of the endogenous hormone progesterone (Cay-15876). 11alpha-OHP (10, 100, and 500 µg/animal) reduces urinary...
| Keywords: | 11alpha-OHP, NSC 3350, U-0384, 11alpha-hydroxy-pregn-4-ene-3,20-dione |
| Application: | 11-HSD inhibitor, progesterone derivative |
| CAS | 80-75-1 |
| MW: | 330.5 D |
From 154.00€
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Cholestyramine
Item number: Cay37827-500
Cholestyramine is a bile acid sequestrant. It binds to bile acids in the intestine and inhibits their absorption, which increases the synthesis of bile acids from cholesterol in the liver, thereby lowering serum LDL levels. Cholestyramine reduces serum cholesterol levels and increases bile acid excretion in the...
| Application: | Bile acid sequestrant |
| CAS | 11041-12-6 |
73.00€
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C16 alpha-Glucosylceramide (d18:1/16:0) (synthetic)
Item number: Cay40274-1
C16 alpha-Glucosylceramide is a bioactive glycosphingolipid. It is a precursor in the synthesis of C16 lactosylceramide (Cay-24352) that is formed via metabolism of C16 ceramide (Cay-10681) by glucosylceramide synthase. Inhalation of C16 glucosylceramide reduces lung colonization by P. aeruginosa and increases...
| Keywords: | GluCer(d18:1/16:0), N-omega-CD3-Hexadecanoyl-glucopsychosine,... |
| Application: | Glycosphingolipid |
| CAS | 74365-77-8 |
| MW: | 700 D |
From 216.00€
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Lipid 88
Item number: Cay40493-1
Lipid 88 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. LNPs containing lipid 88 and encapsulating mRNA encoding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein increase anti-spike glycoprotein IgG...
| Keywords: | tetrakis(2-((((2-butyloctyl)oxy)carbonyl)oxy)ethyl)... |
| Application: | Ionizable cationic lipid, LNP formation |
| CAS | 2982842-99-7 |
| MW: | 1459 D |
From 116.00€
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Ionizable Lipid 4
Item number: Cay40496-10
Ionizable lipid 4 is an ionizable cationic lipid (pKa = 6.1) and a hydrogen peroxide-induced rearrangement product of the cationic lipid CA-lipid 5. Charge-altering lipid nanoparticles (CALNPs) containing CA-lipid 5 and encapsulating siRNA against EGFP undergo hydrogen peroxide-induced removal of the phenylboronic...
| Keywords: | 9,12-octadecadienoic acid, (9Z,12Z)-1,1'-[2-[[[[3-(diethylamino)propoxy]carbonyl]oxy]methyl]-1,3-propanediyl] ester |
| Application: | Ionizable cationic lipid, LNP formation |
| CAS | 1799316-81-6 |
| MW: | 788.2 D |
From 147.00€
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Lipid DIM1
Item number: Cay40512-10
Lipid DIM1 is an ionizable cationic lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for mRNA delivery in vitro. LNPs containing lipid DIM1 and encapsulating mRNA encoding a luciferase reporter induce luminescence in primary mouse adipose stem cells...
| Keywords: | 1,1',1'',1'''-(((((3R,3aS,6S,6aS)-hexahydrofuro[3,2-b]furan-3,6-diyl)bis(oxy))bis(propane-3,1-diyl))bis(azanetriyl))tetrak... |
| Application: | Ionizable cationic lipid, LNP formation |
| CAS | 2820155-36-8 |
| MW: | 997.6 D |
From 112.00€
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Phytantriol
Item number: Cay40742-1
Phytantriol is an aliphatic alcohol that has been used in the formation of liquid crystalline nanoparticles (LCNPs) and cubosomes. Cubosomes containing phytantriol are bactericidal against LPS-deficient and polymyxin-resistant A. baumannii strains. LCNPs containing phytantriol and encapsulating the isoquinoline...
| Keywords: | 3,7,11,15-tetramethyl-1,2,3-hexadecanetriol |
| Application: | Aliphatic alcohol, LCNP formation |
| CAS | 74563-64-7 |
| MW: | 330.6 D |
From 73.00€
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