No results were found for the filter!
D159687
Item number: Cay38778-10
D159687 is a negative allosteric modulator of phosphodiesterase 4D (PDE4D, IC50 = 28 nM for the human enzyme). It is selective for PDE4D over PDE4B (IC50 = 562 nM for the human enzyme), as well as 14 other PDE isoforms (IC50s = >1.4 µM). D159687 decreases forskolin-induced cAMP hydrolysis in HEK293 cells (IC50 = 253...
| Keywords: | N-[4-[(3'-chloro-6-methoxy[1,1'-biphenyl]-3-yl)methyl]phenyl]-urea |
| Application: | Negative allosteric PDE4D modulator |
| CAS | 1155877-97-6 |
| MW: | 366.8 D |
From 91.00€
*
CL4F8-6
Item number: Cay38802-1
CL4F8-6 is an ionizable cationic lipid (pKa = 6.14) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing CL4F8-6 and encapsulating an mRNA reporter accumulate specifically in the mouse liver. LNPs containing CL4F8-6 and...
| Keywords: | 7-(4-(dipropylamino)butyl)-7-hydroxytridecane-1,13-diyl bis(2-hexyloctanoate) |
| Application: | Ionizable cationic lipid, LNP formation |
| CAS | 2766493-12-1 |
| MW: | 808.4 D |
From 118.00€
*
Lipid 23
Item number: Cay38862-10
Lipid 23 is an ionizable cationic amino lipid (pKa = 5.7) that has been used with other lipids in the formulation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing lipid 23 and encapsulating an mRNA reporter accumulate specifically in the mouse liver.Formal Name:...
| Keywords: | 8-((2-((4-(dimethylamino)butanoyl)oxy)ethyl)(10-oxo-10-(tridecan-7-yloxy)decyl)amino)octyl 2-hexyldecanoate |
| Application: | Ionizable cationic amino lipid, LNP formation |
| MW: | 893.5 D |
From 556.00€
*
Dimethyldimyristylammonium (bromide)
Item number: Cay38870-1
Dimethyldimyristylammonium is a cationic lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Administration of LNPs containing dimethyldimyristylammonium and encapsulating mRNA encoding a luciferase reporter increase fluorescence in HeLa cells.Formal Name:...
| Keywords: | Dimethylditetradecylammonium, N,N-dimethyl-N-tetradecyl-1-tetradecanaminium, monobromide |
| Application: | Cationic lipid, LNP formation |
| CAS | 68105-02-2 |
| MW: | 518.7 D |
From 40.00€
*
Tauro-Obeticholic Acid (sodium salt)
Item number: Cay38878-1
Tauro-obeticholic acid is an active metabolite of obeticholic acid, which is a farnesoid X receptor (FXR) agonist and semisynthetic derivative of chenodeoxycholic acid (Cay-10011286). Tauro-obeticholic acid is formed from obeticholic acid by taurine conjugation in the liver but can be reconverted back to obeticholic...
| Keywords: | Obeticholic Acid Taurine Conjugate, Tauro-6-Ethyl-CDCA, Tauro-6-Ethylchenodeoxycholic Acid, Tauro-OCA, T-ECDCA,... |
| Application: | Obeticholic acid active metabolite, choleretic |
| CAS | 2278141-79-8 |
| MW: | 549.7 D |
From 251.00€
*
RM 133-3
Item number: Cay38917-10
RM 133-3 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. LNPs containing RM 133-3 and encapsulating mRNA encoding human erythropoietin (EPO) increase serum human EPO protein levels in mice.Formal Name:...
| Keywords: | (9Z,9'Z)-((3,3'-((3-(diethylamino)propyl)azanediyl)bis(propanoyl))bis(oxy))bis(octadec-9-ene-18,7-diyl)... |
| Application: | Ionizable cationic lipid, LNP formation |
| CAS | 2941228-90-4 |
| MW: | 1376.2 D |
From 391.00€
*
(±)7(S),8(R)-EDT
Item number: Cay38933-100
(±)7(S),8(R)-EDT is an oxylipin.Formal Name: (2R,3S)-rel-3-(2Z,5Z,8Z)-2,5,8-tetradecatrien-1-yl-2-oxiranehexanoic acid. CAS Number: 355016-21-6. Synonyms: (±)-Dihomo-7(S),8(R)-EET, (±)7(S),8(R)-EpDoTrE. Molecular Formula: C22H36O3. Formula Weight: 348.5. Purity: >95%. Formulation: (Request formulation change), A...
| Keywords: | 7,8-EpDoTrE, 7,8-Epoxydocosatrienoic Acid, Dihomo-7,8-EET, 3-(2Z,5Z,8Z)-2,5,8-tetradecatrien-1-yl-2-oxiranehexanoic acid |
| Application: | Adrenic acid metabolite, oxylipin |
| CAS | 355016-21-6 |
| MW: | 348.5 D |
From 76.00€
*
p-methyl-N-salicyloyl Tryptamine
Item number: Cay38958-10
p-methyl-N-salicyloyl Tryptamine is a neuroprotective agent and derivative of N-salicyloyl tryptamine. It reduces LPS-induced nitric oxide (NO) production in C6 rat glioma cells and BV-2 mouse microglia (IC50s = 7.48 and 4.94 µM, respectively). It also reduces LPS-induced production of TNF-alpha and prostaglandin E2...
| Keywords: | para-methyl-N-salicyloyl Tryptamine, LZWL02003, 2-hydroxy-N-[2-(1H-indol-3-yl)ethyl]-4-methyl-benzamide |
| Application: | Neuroprotective agent |
| CAS | 1371564-45-2 |
| MW: | 294.4 D |
From 85.00€
*
13(Z)-Docosenoic Acid (sodium salt)
Item number: Cay38975-10
13(Z)-Docosenoic acid is a 22-carbon monounsaturated fatty acid. Dietary administration of 13(Z)-docosenoic acid (6.6% w/w) increases weight gain and heart triglyceride levels in calcium-deprived weanling rats.CAS Number: 14488-85-8. Synonyms: C22:1(13Z), C22:1 n-9, cis-13-Docosenoic Acid, Erucic Acid, FA 22:1,...
| Keywords: | cis-13-Docosenoic Acid, C22:1 n-9, C22:1(13Z), Erucic Acid, Sodium Erucate |
| Application: | 22-carbon monounsaturated fatty acid |
| CAS | 14488-85-8 |
| MW: | 360.6 D |
From 47.00€
*
DORI
Item number: Cay38981-1
DORI is a cationic lipid that has been used in the formation of liposomes for the delivery of plasmid DNA in vitro.Formal Name: N-(2-hydroxyethyl)-N,N-dimethyl-2,3-bis[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-1-propanaminium, monobromide. CAS Number: 153312-59-5. Synonyms: 1,2-Dioleoyl-3-dimethyl-hydroxyethylammonium...
| Keywords: | 1,2-Dioleoyl-3-dimethyl-hydroxyethylammonium bromide,... |
| Application: | Cationic lipid, LNP formation |
| CAS | 153312-59-5 |
| MW: | 773 D |
From 42.00€
*
1,2-Distearoyl-sn-glycero-3-PC (solution)
Item number: Cay39189-1
1,2-Distearoyl-sn-glycero-3-PC is a phospholipid containing stearic acid (Cay-10011298) at the sn-1 and sn-2 positions. It has commonly been used in the generation of micelles, liposomes, and other types of artificial membranes.Formal Name: 1,2-distearoyl-sn-glycero-3-phosphatidylcholine. CAS Number: 816-94-4....
| Keywords: | 1,2-Distearoyl-sn-glycero-3-Phosphocholine, 1,2-DSPC, 18:0/18:0-PC, Coatsome MC 8080, PC(18:0/18:0),... |
| Application: | Phospholipid, micelle/liposome formation |
| CAS | 816-94-4 |
| MW: | 790.2 D |
From 62.00€
*
Lipid III-45
Item number: Cay39243-10
Lipid III-45 is an ionizable cationic lipid (pKa = 6.25). It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. LNPs containing lipid III-45 and encapsulating a luciferase mRNA reporter accumulate in liver and adipose tissue in mice. LNPs containing lipid III-45 have been...
| Keywords: | Cationic Lipid A, 2-butyl-octanoic acid, 1,1'-[[(3-hydroxypropyl)imino]di-9,1-nonanediyl] ester |
| Application: | Ionizable cationic lipid, LNP formation |
| CAS | 2096984-25-5 |
| MW: | 724.2 D |
From 205.00€
*