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Leukotriene E4
Item number: Cay20410-25
Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4, leaving only the cysteinyl group still attached to the fatty acid backbone. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities...
| Keywords: | LTE4, 5S-hydroxy-6R-(S-cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 75715-89-8 |
| MW: | 439.6 D |
From 197.00€
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Prostaglandin D2-d4
Item number: Cay312010-25
Prostaglandin D2-d4 (PGD2-d4) is intended for use as an internal standard for the quantification of PGD2 by GC- or LC-mass spectrometry. PGD2 is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of...
| Keywords: | PGD2-d4, 9alpha,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4 acid |
| Application: | Standard |
| CAS | 211105-29-2 |
| MW: | 356.5 D |
From 128.00€
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(±)12(13)-DiHOME
Item number: Cay10009832-100
(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME (Cay-52450), a cytochrome P450-derived epoxide of linoleic acid (Cay-90150, Cay-90150.1, Cay-21909) also known as isoleukotoxin. It is formed from 12(13)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils. 12(13)-DiHOME is toxic to Sf21 cells expressing sEH...
| Keywords: | Isoleukotoxin diol, 12,13-dihydroxy-9Z-octadecenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 263399-35-5 |
| MW: | 314.5 D |
From 44.00€
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2-Arachidonoyl Glycerol-d5
Item number: Cay362162-100
2-Arachidonoyl glycerol-d5 (2-AG-d5) is intended for use as an internal standard for the quantification of 2-AG (Cay-62160) by GC- or LC-MS. 2-AG is an endogenous agonist of the CB1 receptor. Unlike anandamide, 2-AG is present at relatively high levels in the central nervous system, it is the most abundant molecular...
| Keywords: | 2-AG-d5, 5Z,8Z,11Z,14Z-eicosatetraenoic acid, 2-glycerol-1,1,2,3,3-d5 ester |
| Application: | Standard |
| CAS | 2522598-88-3 |
| MW: | 383.6 D |
From 121.00€
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(±)17-HDHA
Item number: Cay33650-25
(±)17-HDHA is an autoxidation product of docosahexaenoic acid (DHA, Cay-90310) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. 17(S)-HDHA (Cay-10009799) could be produced by enzymatic oxidation of DHA using soybean lipoxygenase (LO) and is the putative product of...
| Keywords: | (±)17-HDoHE, 17-hydroxy Docosahexaenoic Acid, 17-hydroxy DHA, (±)17-hydroxy-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid |
| Application: | Oxidative stress marker |
| CAS | 90780-52-2 |
| MW: | 344.5 D |
From 92.00€
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1,2-Dipalmitoyl-sn-glycero-3-PC
Item number: Cay10009473-100
1,2-Dipalmitoyl-sn-glycero-3-PC (1,2-DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications. It has been used in the formation of proteoliposomes for implantation of gamma-glutamyl transpeptidase into human...
| Keywords: | 1,2-Dipalmitoyl-sn-glycero-3-Phosphatidylcholine, 16:0/16:0-PC, DPPC, L-Dipalmitoyl Lecithin, PC(16:0/16:0),... |
| Application: | Zwitterionic glycerophospholipid, lipid monolayer formation |
| CAS | 63-89-8 |
| MW: | 734.1 D |
From 135.00€
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13(S)-HODE-d4
Item number: Cay338610-25
13(S)-HODE-d4 is intended for use as an internal standard for the quantification of 13-HODE by GC- or LC-MS. (±)-13-HODE is formed via non-enzymatic oxidation of linoleic acid (Cay-90150, Cay-90150.1, Cay-21909). 13(S)-HODE and 13(R)-HODE are formed by lipoxygenase- and cyclooxygenase-mediated oxidation of linoleic...
| Keywords: | 13S-hydroxy-9Z,11E-octadecadienoic-9,10,12,13-d4 acid |
| Application: | Standard |
| CAS | 139408-39-2 |
| MW: | 300.5 D |
From 184.00€
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5(S)-HETE
Item number: Cay34230-25
5(S)-HETE is produced by the action of 5-LO on arachidonic acid to give 5(S)-HpETE, followed by reduction of the hydroperoxide. 5(S)-HETE has proliferative and chemotactic effects on granulocytes. When further metabolized to 5-oxoETE, it is a more potent eosinophil chemoattractant than leukotriene B4.Formal Name:...
| Keywords: | 5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 70608-72-9 |
| MW: | 320.5 D |
From 155.00€
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1-Octadecyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)
Item number: Cay10010291-10
1-Oleyl-2-hydroxy-sn-glycero-3-PA (1-Octadecyl LPA) is a LPA analog containing stearyl alcohol at the sn-1 position. LPA binds to one of five different G protein-linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite...
| Keywords: | 1-Octadecyl LPA, 1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphate, monosodium salt |
| Application: | Lysophosphatidic (LPA) analog |
| MW: | 446.5 D |
442.00€
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DOG-IM4
Item number: Cay37441-1
DOG-IM4 is an ionizable cationic lipid (apparent pKa = 5.6) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. Immunization with LNPs containing DOG-IM4 and encapsulating mRNA encoding influenza A hemagglutinin (HA) increases HA-inhibiting antibody titers (HI titers) in mice...
| Keywords: | N-[(25Z)-14-[(9Z)-9-octadecen-1-yloxy]-3,6,9,12,16-pentaoxatetratriacont-25-en-1-yl]-1H-imidazole-5-carboxamide |
| Application: | Ionizable cationic lipid, LNP formation, mRNA delivery |
| CAS | 2758097-38-8 |
| MW: | 862.3 D |
From 84.00€
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306-O12B
Item number: Cay37549-10
306-O12B is an ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing 306-O12B and encapsulating an mRNA reporter accumulate specifically in the mouse liver. LNPs containing 306-O12B and encapsulating mRNA encoding the Cas9...
| Keywords: | tetrakis(2-(octyldisulfaneyl)ethyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate |
| Application: | Ionizable cationic lipidoid, LNP formation |
| CAS | 2566523-06-4 |
| MW: | 1251.1 D |
From 144.00€
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IR-117-17
Item number: Cay40420-10
IR-117-17 is an ionizable cationic and biodegradable amino lipid. It has been used in the generation of lipid nanoparticles (LNPs). Nebulized administration of LNPs containing IR-117-17 and the cationic lipid 1,2-dioleoyl-2-trimethylammoniumpropane (1,2-DOTAP, Cay-15110), among other components, and encapsulating...
| Keywords: | A10-LIN, 5-(((3-(dibutylamino)propyl)amino)methyl)-6-hydroxyundecane-1,11-diyl (9Z,9'Z,12Z,12'Z)-bis(octadeca-9,12-dienoate) |
| Application: | Ionizable cationic, biodegradable amino lipid, LNP formation |
| CAS | 2940241-38-1 |
| MW: | 927.5 D |
From 473.00€
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