5-OxoETE

5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils by a specific dehydrogenase. It stimulates cytosolic calcium levels in neutrophils with an EC50 value of 2 nM. 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway in stimulated neutrophils via a specific G protein-coupled receptor.Formal Name: 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid. CAS Number: 106154-18-1. Synonyms: 5-KETE. Molecular Formula: C20H30O3. Formula Weight: 318.5. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: Miscible, DMSO: Miscible, Ethanol: Miscible, PBS pH 7.2: 0.8 mg/ml. lambdamax: 279 nm. SMILES: CCCCC/C=C\C/C=C\C/C=C\C=C/C(=O)CCCC(=O)O. InChi Code: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+. InChi Key: MEASLHGILYBXFO-XTDASVJISA-N.