5-Aminosalicylic Acid-d7

5-Aminosalicylic acid-d7 (5-ASA-d7) is intended for use as an internal standard for the quantification of 5-ASA (Cay-70265) by GC- or LC-MS. 5-ASA is a non-steroidal anti-inflammatory drug (NSAID) and an active metabolite of sulphasalazine (Cay-15025), basalazide (Cay-18680), and olsalazine (Cay-23661). It selectively inhibits COX-2 over COX-1 in isolated human whole blood (IC50s = 61 and 410 µM, respectively). 5-ASA inhibits hemoglobin- and hydrogen peroxide-induced lipid peroxidation in a cell-free assay (IC50 = 50 µM). It also inhibits the synthesis of leukotriene B4 (LTB4, Cay-20110) in isolated human mucosal cells when used at a concentration of 100 µM. Formulations containing 5-ASA have been used in the treatment of inflammatory bowel disease (IBD) and ulcerative colitis.Formal Name: 5-(amino-d2)-2-(hydroxy-d)benzoic-d3 acid-d. Synonyms: 5-ASA-d7, Mesalamine-d7, Mesalazine-d7. Molecular Formula: C7D7NO3. Formula Weight: 160.2. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: 1M HCl: soluble, DMSO: 4 mg/ml, Ethanol: soluble, Water: soluble. SMILES: [2H]C1=C(C(O[2H])=O)C(O[2H])=C([2H])C([2H])=C1N([2H])[2H]. InChi Code: InChI=1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)/i1D,2D,3D/hD4. InChi Key: KBOPZPXVLCULAV-PNENHCSXSA-N.