(±)-4-CMTB

(±)-4-CMTB is a positive allosteric modulator of free fatty acid receptor 2 (FFAR2/GPR43) with an EC50 value of 0.42 µM for [35S]GTPgammaS binding to 293 T-REx cell membranes expressing the human receptor. It selectively induces ERK1/2 phosphorylation in 293 T-REx cells expressing human FFAR2, but not FFAR1 or FFAR3.Formal Name: 4-chloro-alpha-(1-methylethyl)-N-2-thiazolyl-benzeneacetamide. CAS Number: 300851-67-6. Molecular Formula: C14H15ClN2OS. Formula Weight: 294.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 0.3mg/mL, DMSO: 5mg/mL, DMSO:PBS (pH 7.2) (1:2): 0.3mg/mL, Ethanol: 3mg/mL. lambdamax: 223, 269 nm. SMILES: ClC1=CC=C(C(C(C)C)C(NC2=NC=CS2)=O)C=C1. InChi Code: InChI=1S/C14H15ClN2OS/c1-9(2)12(10-3-5-11(15)6-4-10)13(18)17-14-16-7-8-19-14/h3-9,12H,1-2H3,(H,16,17,18). InChi Key: AZYDQCGCBQYFSE-UHFFFAOYSA-N.